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AGTR2 — MAPK1
Text-mined interactions from Literome
Zimpelmann et al., American journal of physiology. Renal physiology 2001
:
In summary,
AT(2) receptors in proximal tubule cells
inhibit MAPK activity and stimulate phosphotyrosine phosphatase
Sekine et al., Arch Biochem Biophys 2003
:
AT II also
activated the extracellular signal regulated kinase ( ERK ) and p38
MAPK in the presence of AT II
Kumar et al., J Cardiovasc Pharmacol Ther 2003
(Disease Models, Animal...) :
Our aim was to assess the
effect of selective AT1 and
AT2 receptor blockade with losartan and PD123,319, respectively, on
MAPK expression after ischemia-reperfusion in isolated working rat hearts
Moore et al., Brain Res Mol Brain Res 2004
:
Human
angiotensin II type-2 receptor inhibition of insulin mediated
ERK-2 activity via a G-protein coupled signaling pathway ... Our results support the hypothesis that the
AT(2) receptor
inhibits insulin induced
ERK-2 activity via a G-protein coupled pathway involving the up-regulation of PP2A
Li et al., American journal of physiology. Renal physiology 2012
(MAP Kinase Signaling System) :
We conclude that intracellular ANG II may induce NHE3 expression and activation in mPCTs via AT ( 1a ) - and
AT(2) receptor
mediated activation of MAP kinases
ERK 1/2 and NF-?B signaling pathways
Hayashida et al., J Biol Chem 1996
:
The antagonistic
effect of the
AT2-3LP on
mitogen activated protein kinase activity and DNA synthesis were reversed by pertussis toxin and sodium orthovanadate
Shenoy et al., Endocrinology 1999
:
Concurrent activation of c-Jun N-terminal kinase (JNK) and inhibition of Erk mitogen activated protein kinase activities is important for apoptosis in many cells, and we previously demonstrated that stimulation of
AT2 receptors
causes decreased
mitogen activated protein kinase activity in neurons cultured from newborn rat hypothalamus and brain stem
McNeill et al., Endocr Res 1998
:
Therefore, MAPK is located in the glomerulosa, where the AT1 receptor is localised and concerned with aldosterone biosynthesis, and in the medulla where
MAPK activation
results from
AT2R activation