Gene interactions and pathways from curated databases and text-mining

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AKT2 — E2F1

Text-mined interactions from Literome

Gille et al., J Biol Chem 1999 : Activated PI 3-kinase induces cyclin D(1) transcription and E2F activity, at least in part mediated by the serine/threonine kinase Akt/PKB , and to a lesser extent the Rho family GTPase Rac
Chaussepied et al., Mol Cell 2004 : Transcriptional regulation of AKT activation by E2F ... We identify the adaptor protein Grb2 associated binder 2 (Gab2) as a direct E2F target gene and an essential effector of E2F dependent AKT activation
Yin et al., Prostate 2009 (Prostatic Neoplasms) : In prostate cancer C/EBPalpha promotes cell growth by the loss of interactions with CDK2, CDK4, and E2F and by activation of AKT
Lee et al., Oncogene 2009 (Prostatic Neoplasms) : MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1 mediated suppression of Akt phosphorylation ... After overexpressing of miR-330 in PC-3 cells, cell growth was suppressed by reducing E2F1 mediated Akt phosphorylation and thereby inducing apoptosis ... Collectively, this is the first study to show that E2F1 is negatively regulated by miR-330 and also show that miR-330 induces apoptosis in prostate cancer cells through E2F1 mediated suppression of Akt phosphorylation
Dar et al., J Biol Chem 2011 (Melanoma...) : The proliferative capacity of melanoma cells was suppressed by miR-205 and mediated by E2F regulated AKT phosphorylation