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ANPEP — TLR4

Text-mined interactions from Literome

Wilk et al., Eur J Immunol 2013 : Toll-like receptor ( TLR ) ligand induced IFN-? production was diminished by APN while it had no influence on NK-cell cytotoxicity
Jenke et al., Cardiovasc Res 2013 : APN overexpression in murine experimental autoimmune myocarditis ( EAM ) down-regulated cardiac expression of TLR4 and its downstream targets tumour necrosis factor ( TNF ) a, interleukin (IL)-6, IL-12, CC chemokine ligand (CCL)2, and intercellular adhesion molecule (ICAM)-1 resulting in reduced infiltration with cluster of differentiation ( CD ) 3+, CD14+, and CD45+ immune cells as well as diminished myocardial apoptosis ... In vitro APN had no effect on TLR4 expression in cardiac and immune cells but induced dissociation of APN receptors from the activated TLR4/CD14 signalling complex ... Mechanistically, APN inhibited TLR4 signalling through cyclooxygenase (COX)-2, protein kinase A (PKA), and meiosis-specific serine/threonine kinase ( MEK)1