Gene interactions and pathways from curated databases and text-mining

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BMP2 — TLR4

Text-mined interactions from Literome

Su et al., J Biol Chem 2011 : The aim of this study was to determine the effect of oxidized low density lipoprotein ( oxLDL ) on BMP-2 protein expression in human coronary artery endothelial cells ( CAECs ), the roles of Toll-like receptor (TLR) 2 and TLR4 in oxLDL induced BMP-2 expression, and the signaling pathways involved ... The roles of TLR2 and TLR4 in oxLDL induced BMP-2 expression were determined by pretreatment with neutralizing antibody, siRNA, and overexpression ... These findings underscore an important role for TLR2 and TLR4 in mediating the BMP-2 response to oxLDL in human CAECs and indicate that these two immunoreceptors contribute to the mechanisms underlying atherosclerotic vascular calcification
Zeng et al., Arterioscler Thromb Vasc Biol 2013 (Aortic Valve Stenosis...) : Aortic valve interstitial cells ( AVICs ) from stenotic valves express higher levels of bone morphogenetic protein-2 in response to Toll-like receptor 4 stimulation