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BMP2 — WNT16

Text-mined interactions from Literome

McGrew et al., Mech Dev 1999 : The co-activation of Wnt signaling and concomitant inhibition of BMP signaling has previously been implicated in vertebrate neural patterning, as evidenced by the combinatorial induction of engrailed-2 and krox-20 in Xenopus
Fischer et al., J Cell Biochem 2002 : To assess the functional involvement of Wnt signaling in BMP-2 induced chondrogenesis, cultures were treated with lithium chloride, a Wnt-7A mimetic that acts by inhibiting the serine/threonine phosphorylation activity of glycogen synthase kinase-3beta ( GSK-3beta )
Nakashima et al., J Biol Chem 2005 : This suppression is mediated by a GC-rich region of the BMP-2-responsive element of the Id1 gene promoter, and interaction between Smad1/4 and beta-catenin is crucial for Wnt mediated suppression of the BMP-2 response in C2C12 cells ... These findings identify functional cross-talk of Id1 expression between Wnt and BMP signaling and demonstrate a novel mechanism for Wnt regulation of the BMP-2 response, linking Id1 expression to Wnt/beta-catenin signaling
Dong et al., J Cell Physiol 2006 (Hypertrophy) : Altogether we demonstrate that Wnt/beta-catenin signaling is regulated by TGF-beta and BMP-2 in chick upper sternal chondrocytes, and mediates chondrocyte hypertrophy at least partly through activation of Runx2 which in turn may induce col10a1 expression
Liu et al., J Biol Chem 2006 : Expression of a mutant Smad1 protein, which can not be phosphorylated in response to BMP, eliminated the inhibitory effect of BMP on Wnt-inducedbeta-catenin accumulation and transcriptional activity
van Bezooijen et al., J Bone Miner Res 2007 : In contrast, sclerostin shared many characteristics with the Wnt antagonist dickkopf-1 in antagonizing BMP stimulated bone formation and BMP- and Wnt induced Wnt reporter construct activation
Patthey et al., PloS one 2008 : By using in vitro assays of neural crest and placodal cell differentiation, we now provide evidence that Wnt signals impose caudal character on neural plate border cells at the late gastrula stage, and that under these conditions, BMP signals induce neural crest instead of rostral placodal cells
Kami et al., PloS one 2008 : Furthermore, BMP2 inhibited Wnt/beta-catenin signaling that promoted CL6 cardiomyogenesis
Patthey et al., Development 2009 : Our results indicate, however, that at this stage BMP signals can induce neural plate border cells only when Wnt activity is blocked, and that the two signals in combination generate epidermal cells
Sato et al., Genes Cells 2009 : Bone morphogenetic protein-2 enhances Wnt/beta-catenin signaling induced osteoprotegerin expression
Steventon et al., Development 2009 : By performing tissue recombination experiments and using specific inhibitors of different inductive signals, we show that the first inductive step requires Wnt activation and BMP inhibition , whereas the later maintenance step requires activation of both pathways
Kamiya et al., Curr Mol Pharmacol 2012 (Bone Resorption) : We recently generated an osteoblast targeted deletion of BMP signaling using a Cre-loxP strategy and found that BMP signaling in osteoblasts can inhibit Wnt signaling through the Wnt inhibitors DKK1 and SOST
Papathanasiou et al., Arthritis Res Ther 2012 (Hypertrophy...) : Bone morphogenetic protein-2 induced Wnt/ß-catenin signaling pathway activation through enhanced low-density-lipoprotein receptor related protein 5 catabolic activity contributes to hypertrophy in osteoarthritic chondrocytes
Kim et al., Biochem Biophys Res Commun 2012 (Wnt Signaling Pathway) : During vertebrate heart valve formation, Wnt/ß-catenin signaling induces BMP signals in atrioventricular canal ( AVC ) myocardial cells and underlying AVC endocardial cells then undergo endothelial-mesenchymal transdifferentiation ( EMT ) by receiving this BMP signals
Klaus et al., Proc Natl Acad Sci U S A 2012 (Wnt Signaling Pathway) : Using FACS enrichment of cardiac progenitors in RBPJ and RBPJ/Axin2 mutants, embryo cultures in the presence of the Bmp inhibitor Noggin, and by crossing a Bmp4 mutation into the RBPJ/Axin2 mutant background, we show that Wnt and Bmp4 signaling activate specific and nonoverlapping cardiac-specific genes in the cardiac progenitors : Nkx2-5, Isl1 and Baf60c are controlled by Wnt/ß-catenin , and Gata4, SRF, and Mef2c are controlled by Bmp signaling
Zhang et al., Bone 2013 : Wnt/ß-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts ... Activation of Wnt signaling by Wnt3a or overexpression of ß-catenin/TCF4 both stimulated BMP2 transcription at promoter and mRNA levels
Wang et al., PloS one 2013 : Whole embryo cultures treated with Wnt4 or Wnt inhibitory factor 1 (Wif1) show that Bmp2 expression in the AVC myocardium is dependent on Wnt activity ; Wnt4 also reinstates Bmp2 expression in the AVC myocardium of endocardial Notch1 null embryos
Hoppler et al., Mech Dev 1998 : Although BMP-2/-4 signaling regulates Wnt-8 expression, these genes do not function in a linear pathway because Wnt-8 overexpression can not compensate for an inhibition of BMP-2/-4 function, but rather BMP-4 overexpression rescues ventral gene expression in embryos with inhibited Wnt-8 function
Godin et al., Development 1998 : By contrast, BMP7 expression in the metanephric mesenchyme is dependent on proteoglycans and possibly Wnt signaling