Gene interactions and pathways from curated databases and text-mining

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CASP1 — IL2

Text-mined interactions from Literome

Mukerjee et al., Biochem Biophys Res Commun 2001 : It has been previously reported that IL-2 release in activated Jurkat T requires caspase-like activity ( Posmantur et al. ( 1998 ) Exp. Cell
Guo et al., Blood 2003 : In the present study we confirm that Fas signaling induces both phenotypic and functional maturation of murine DCs, and we demonstrate that phenotypic maturation is associated with phosphorylation of extracellular signal regulated kinase ( ERK ) 1/2, activation of caspase-1 , and secretion of interleukin-beta ( IL-1beta )
Falk et al., J Immunol 2004 : Our results demonstrate that caspase inhibition leads to strongly reduced IL-2 release, failure to up-regulate CD25, and a lack of proper regulation of cell cycle associated proteins
Du et al., Kidney Int 2005 : Both IL-2 and IFN-gamma induced TEC apoptosis and activated caspase-8 ... IL-2 did not induce apoptosis in Fas-deficient TECs ( M3.1-lpr ) suggesting IL-2 regulation of caspase-8 activity requires Fas
Wang et al., Ann Thorac Surg 2005 (Reperfusion Injury) : Myocardial tissue was then assessed for products of p38 MAPK activation, expression of tumor necrosis factor, interleukin-1beta and interleukin-6, and activation of caspase-1, caspase-3 and caspase-11
Shushanov et al., Bull Exp Biol Med 2010 : Insulin-like growth factor-1 and insulin inhibit caspase-3/7 activation initiated by interleukin-1ß in the rat eye retinal neurons
Liao et al., Inflamm Res 2013 : Lipopolysaccharide/adenosine triphosphate mediated signal transduction in the regulation of NLRP3 protein expression and caspase-1 mediated interleukin-1ß secretion