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CASP2 — TRAF2

Pathways - manually collected, often from reviews:

• BioCarta tnfr1 signaling pathway: TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD) → Caspase 2 (active) (CASP2) (modification, activates)
  
• BioCarta tnfr1 signaling pathway: TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD) → Caspase 2 (CASP2) (modification, activates)
• BioCarta tnf/stress related signaling: TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A) → MAP4K2 (modification, activates)
• BioCarta tnf/stress related signaling: SODD (BAG4) → TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A) (modification, collaborate)
  
• BioCarta tnf/stress related signaling: TRAF2 → TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A) (modification, collaborate)
  
• BioCarta tnf/stress related signaling: TRAF2 → Caspase 2 (CASP2) (modification, collaborate)
• BioCarta tnf/stress related signaling: TNF-alpha/TNF R1/SODD complex (BAG4-TNFRSF1A-TNF) → TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A) (modification, collaborate)
  
• BioCarta tnf/stress related signaling: TRADD → TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A) (modification, collaborate)
  
• BioCarta tnf/stress related signaling: I-TRAF (TANK) → TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A) (modification, collaborate)
  
• BioCarta tnf/stress related signaling: TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A) → Caspase 2 (CASP2) (modification, collaborate)
• BioCarta tnf/stress related signaling: TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A) → RIP (RIPK1) (modification, collaborate)
• BioCarta hiv-1 nef: negative effector of fas and tnf: TRAF1 → TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) (modification, collaborate)
  
• BioCarta hiv-1 nef: negative effector of fas and tnf: RAIDD (CRADD) → TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) (modification, collaborate)
  
• BioCarta hiv-1 nef: negative effector of fas and tnf: SODD (BAG4) → TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) (modification, collaborate)
  
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) → cIAP2 (BIRC3) (modification, collaborate)
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) → ASK1 (MAP3K5) (modification, collaborate)
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) → TRADD (modification, collaborate)
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) → TRAF2 (modification, collaborate)
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) → Caspase 2 (CASP2) (modification, collaborate)
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) → TNF/TNF R/SODD complex (TNF-BAG4-TNFRSF1A) (modification, collaborate)
  
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) → FADD (modification, collaborate)
• BioCarta hiv-1 nef: negative effector of fas and tnf: TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD) → RIP (RIPK1) (modification, collaborate)
• BioCarta hiv-1 nef: negative effector of fas and tnf: TRAF2 → Caspase 2 (CASP2) (modification, collaborate)
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) → FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD) (modification, activates)
  Micheau et al., Cell 2003, Yang et al., Cell 1997, Saitoh et al., EMBO J 1998, Chang et al., Science 1998
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: RAIDD (CRADD) → TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) (modification, collaborate)
  
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: FADD (FADD) → TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) (modification, collaborate)
  
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: ASK1 (MAP3K5) → TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) (modification, collaborate)
  
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: TRAF1 (TRAF1) → TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) (modification, collaborate)
  
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: cIAP2 (BIRC3) → TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) (modification, collaborate)
  
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: BAG4 (BAG4) → TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) (modification, collaborate)
  
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: Caspase 2 (CASP2) → TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) (modification, collaborate)
  
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: Caspase 2 (CASP2) → TRAF2 (TRAF2) (modification, collaborate)
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: TNFR1A/BAG4/TNF-alpha complex (TNF-BAG4-TNFRSF1A) → TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) (modification, collaborate)
  
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) → TRADD (TRADD) (modification, collaborate)
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) → RIP (RIPK1) (modification, collaborate)
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) → TRAF2 (TRAF2) (modification, collaborate)
• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) → NIK (MAP3K14) (modification, activates) Malinin et al., Nature 1997
• NCI Pathway Database Caspase Cascade in Apoptosis: TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD/PIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF-PIDD1) → Caspase 2 (CASP2) (modification, activates)

Text-mined interactions from Literome

Hentze et al., Hepatology 2004 : CPT treatment completely abrogated the TNF induced NF-kappa B activation, and mRNA expression of the antiapoptotic factors TNF-receptor associated factor 2 , FLICE-inhibitory protein, and X-linked inhibitor of apoptosis protein was also inhibited by CPT. The caspase inhibitors benzyloxycarbonyl-Val-Ala-Asp- ( OMe ) -fluoromethylketone ( zVAD-fmk ) and benzyloxycarbonyl-Asp ( OMe ) -Glu ( OMe ) -Val-Asp ( OMe ) -chloromethylketone ( zDEVD-fmk ), as well as depletion of intracellular ATP by fructose prevented CPT/TNF induced apoptosis
Conti et al., J Neurosurg 2005 (Brain Neoplasms...) : The authors investigated the expression of NF-kappaB, caspase 3, TRAF1, TRAF2, and TRAF associated NF-kappaB activator/TRAF interacting protein ( TANK/I-TRAF ), a regulator of TRAF activity, in human gliomas
Georgopoulos et al., Cell Death Differ 2006 (Urologic Neoplasms) : Thus, TRAF3 stabilization, JNK activation and caspase-9 induction define a novel pathway of CD40 mediated apoptosis in carcinoma cells