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CCNB1 — PCNA
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
PCNA
—
CCNB1
(physical association, affinity chromatography technology)
Zhang et al., Mol Biol Cell 1993
-
MIPS CORUM Cell cycle kinase complex CDC2:
Cell cycle kinase complex CDC2 complex (CCNB1-CCNB2-CCND1-CDK1-CDKN1A-PCNA)
Zhang et al., Mol Biol Cell 1993
-
MIPS CORUM CDC2-PCNA-CCNB1-GADD45A complex:
CDC2-PCNA-CCNB1-GADD45A complex complex (CCNB1-CDK1-GADD45A-PCNA)
Vairapandi et al., J Cell Physiol 2002
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MIPS CORUM CDC2-PCNA-CCNB1-GADD45B complex:
CDC2-PCNA-CCNB1-GADD45B complex complex (CCNB1-CDK1-GADD45B-PCNA)
Vairapandi et al., J Cell Physiol 2002
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MIPS CORUM CDC2-PCNA-CCNB1-GADD45G complex:
CDC2-PCNA-CCNB1-GADD45G complex complex (CCNB1-CDK1-GADD45G-PCNA)
Vairapandi et al., J Cell Physiol 2002
-
IRef Corum Interaction:
Complex of CDK1-CDK1-PCNA-PCNA-CCNB1-CCNB1-GADD45A-GADD45A
(association, pull down)
Vairapandi et al., J Cell Physiol 2002
-
IRef Corum Interaction:
Complex of CCNB2-CDKN1A-CCNB1-PCNA-CDK1-CCND1
(association, anti bait coimmunoprecipitation)
Zhang et al., Mol Biol Cell 1993
-
IRef Corum Interaction:
Complex of GADD45B-GADD45B-CDK1-CDK1-PCNA-PCNA-CCNB1-CCNB1
(association, coimmunoprecipitation)
Vairapandi et al., J Cell Physiol 2002
-
IRef Corum Interaction:
Complex of GADD45G-GADD45G-CDK1-CDK1-PCNA-PCNA-CCNB1-CCNB1
(association, coimmunoprecipitation)
Vairapandi et al., J Cell Physiol 2002
-
IRef Hprd Interaction:
Complex of 33 proteins
(in vivo)
Ando et al., J Biol Chem 2001*
-
IRef Hprd Interaction:
PCNA
—
CCNB1
(in vivo)
Xiong et al., Genes Dev 1993*
-
IRef Ophid Interaction:
PCNA
—
CCNB1
(aggregation, confirmational text mining)
Xiong et al., Genes Dev 1993*
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IRef Ophid Interaction:
PCNA
—
CCNB1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Shen et al., Zhonghua Zhong Liu Za Zhi 2002
:
In the synchronized growing cells,
cyclin B1 was mainly
detected in the early G ( 1 ) phase, while in transformed T7 cells,
cyclin B1 was mainly detected in the late G ( 1 ) phase
Shen et al., Cancer Res 2004
(Neoplasms) :
For the asynchronously growing T-7 cells,
cyclin B1 was
detected in early G ( 1 ) phase, whereas in MOLT-4 cells arrested in G ( 1 ) -S phase,
cyclin B1 was mainly detected in late G ( 1 ) phase
Swiatek et al., FEBS Lett 2004
:
We demonstrate that JA prevents the accumulation of B-type
cyclin dependent kinases and the expression of
cyclin B1 ; 1, which are both essential for the initiation of mitosis
Rodriguez-Pinilla et al., Clin Cancer Res 2004
(Carcinoma, Squamous Cell...) :
Evaluation of the simultaneous expression of different proteins highlighted direct correlations ( P < 0.05 ) such as that of the cyclin dependent kinases with their cyclin-partners, and the Ki-67 protein with
cyclin dependent kinases 1, cyclin A (CA) and
cyclin B1
Santin et al., Virology 2005
(Uterine Cervical Neoplasms) :
Cyclin dependent kinase inhibitor 2A ( CDKN2A/p16 ), mesoderm-specific transcript, forkhead box M1, v-myb myeloblastosis viral oncogene homolog ( avian ) -like2 ( v-Myb ), minichromosome maintenance proteins 2, 4, and 5,
cyclin B1 , prostaglandin E synthase (PTGES), topoisomerase II alpha (TOP2A), ubiquitin conjugating enzyme E2C, CD97 antigen, E2F transcription factor 1, and dUTP pyrophosphatase were among the most highly overexpressed genes in CVX when compared to NCK
Leisenfelder et al., J Virol 2006
:
Cyclin dependent kinases (CDKs) and cyclins displayed a highly unusual profile in VZV infected confluent fibroblasts : total amounts of CDK1, CDK2, cyclin B1, cyclin D3, and cyclin A protein increased, and kinase activities of CDK2, CDK4, and
cyclin B1 were strongly and simultaneously
induced
Seifert et al., Cell Signal 2009
:
Activation of caspase-9 is inhibited by phosphorylation at Thr125, which is catalysed by the mitogen activated protein kinases ( MAPKs ) ERK1/2 in response to growth factors, by the
cyclin dependent protein kinase
CDK1-cyclin B1 during mitosis, and at a basal level by the dual-specificity tyrosine-phosphorylation regulated protein kinase DYRK1A
Fidalgo da Silva et al., Cell cycle (Georgetown, Tex.) 2011
(Tuberous Sclerosis) :
Herein, we demonstrate that tuberin binds and
regulates the G 2/M
cyclin ,
cyclin B1
Moro et al., Biochem Mol Biol Int 1997
:
To our knowledge this is the first report showing positive
effect of cyclin A,
cyclin E and cyclin D1 on
cyclin B1 activation and blocking of this activation by a Cdk2 dominant negative mutant
Katula et al., Cell Growth Differ 1997
:
Cyclin dependent kinase activation and S-phase
induction of the
cyclin B1 gene are linked through the CCAAT elements ...
Induction of
cyclin B1 by
cyclin/cyclin dependent kinase (cdk) complexes were examined by cotransfection of the reporter along with appropriate expression vectors
Ling et al., Int J Cancer 1998
(Carcinoma, Squamous Cell) :
In contrast, the endonuclease inhibitors aurintricarboxilic acid and zinc markedly inhibited taxol induced DNA ladder fragmentation without altering taxol induced cell-cycle arrest,
cyclin B1 accumulation,
activation of
cyclin B1 kinase activity and cytotoxicity