Gene interactions and pathways from curated databases and text-mining

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CCNB1 — PCNA

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Shen et al., Zhonghua Zhong Liu Za Zhi 2002 : In the synchronized growing cells, cyclin B1 was mainly detected in the early G ( 1 ) phase, while in transformed T7 cells, cyclin B1 was mainly detected in the late G ( 1 ) phase
Shen et al., Cancer Res 2004 (Neoplasms) : For the asynchronously growing T-7 cells, cyclin B1 was detected in early G ( 1 ) phase, whereas in MOLT-4 cells arrested in G ( 1 ) -S phase, cyclin B1 was mainly detected in late G ( 1 ) phase
Swiatek et al., FEBS Lett 2004 : We demonstrate that JA prevents the accumulation of B-type cyclin dependent kinases and the expression of cyclin B1 ; 1, which are both essential for the initiation of mitosis
Rodriguez-Pinilla et al., Clin Cancer Res 2004 (Carcinoma, Squamous Cell...) : Evaluation of the simultaneous expression of different proteins highlighted direct correlations ( P < 0.05 ) such as that of the cyclin dependent kinases with their cyclin-partners, and the Ki-67 protein with cyclin dependent kinases 1, cyclin A (CA) and cyclin B1
Santin et al., Virology 2005 (Uterine Cervical Neoplasms) : Cyclin dependent kinase inhibitor 2A ( CDKN2A/p16 ), mesoderm-specific transcript, forkhead box M1, v-myb myeloblastosis viral oncogene homolog ( avian ) -like2 ( v-Myb ), minichromosome maintenance proteins 2, 4, and 5, cyclin B1 , prostaglandin E synthase (PTGES), topoisomerase II alpha (TOP2A), ubiquitin conjugating enzyme E2C, CD97 antigen, E2F transcription factor 1, and dUTP pyrophosphatase were among the most highly overexpressed genes in CVX when compared to NCK
Leisenfelder et al., J Virol 2006 : Cyclin dependent kinases (CDKs) and cyclins displayed a highly unusual profile in VZV infected confluent fibroblasts : total amounts of CDK1, CDK2, cyclin B1, cyclin D3, and cyclin A protein increased, and kinase activities of CDK2, CDK4, and cyclin B1 were strongly and simultaneously induced
Seifert et al., Cell Signal 2009 : Activation of caspase-9 is inhibited by phosphorylation at Thr125, which is catalysed by the mitogen activated protein kinases ( MAPKs ) ERK1/2 in response to growth factors, by the cyclin dependent protein kinase CDK1-cyclin B1 during mitosis, and at a basal level by the dual-specificity tyrosine-phosphorylation regulated protein kinase DYRK1A
Fidalgo da Silva et al., Cell cycle (Georgetown, Tex.) 2011 (Tuberous Sclerosis) : Herein, we demonstrate that tuberin binds and regulates the G 2/M cyclin , cyclin B1
Moro et al., Biochem Mol Biol Int 1997 : To our knowledge this is the first report showing positive effect of cyclin A, cyclin E and cyclin D1 on cyclin B1 activation and blocking of this activation by a Cdk2 dominant negative mutant
Katula et al., Cell Growth Differ 1997 : Cyclin dependent kinase activation and S-phase induction of the cyclin B1 gene are linked through the CCAAT elements ... Induction of cyclin B1 by cyclin/cyclin dependent kinase (cdk) complexes were examined by cotransfection of the reporter along with appropriate expression vectors
Ling et al., Int J Cancer 1998 (Carcinoma, Squamous Cell) : In contrast, the endonuclease inhibitors aurintricarboxilic acid and zinc markedly inhibited taxol induced DNA ladder fragmentation without altering taxol induced cell-cycle arrest, cyclin B1 accumulation, activation of cyclin B1 kinase activity and cytotoxicity