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CD274 — IFNG

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CD274 → IFNG (increases)
  Evidence: Spontaneous or IFNg-induced PD-L1/B7-H1 expression on tumor cells contribute to impaired T-cell effector functions or apoptosis (Dong et al., 2002; Hirano et al., 2005).

Text-mined interactions from Literome

Petroff et al., Placenta 2002 (Choriocarcinoma...) : Further, treatment of the choriocarcinoma cell line, JEG-3, with recombinant human interferon (IFN)-gamma resulted in a dose dependent increase in the abundance of the message for B7-H1, suggesting that IFN-gamma could regulate expression of B7-H1 by the trophoblast
Mazanet et al., J Immunol 2002 (Inflammation) : B7-H1 is not expressed constitutively by ECs ; however, it is rapidly induced by IFN-gamma , and synergistically by IFN-gamma and TNF
Tamura et al., Int J Hematol 2003 (Autoimmune Diseases...) : Upon binding to an as yet unidentified costimulatory receptor on primed T-cells, B7-H1 costimulates T-cell proliferation and preferentially induces interleukin 10 and interferon gamma
Schoop et al., Nephrol Dial Transplant 2004 : Suppressed T-cell activation by IFN-gamma induced expression of PD-L1 on renal tubular epithelial cells ... Upon stimulation with IFN-gamma , a dose dependent upregulation of PD-L1 expression was observed
Saudemont et al., Blood 2005 (Leukemia, Myeloid, Acute) : Mouse and human B7-H1+ NK cells induced proliferation of T cells and production of interferon gamma and tumor necrosis factor alpha in vitro, and in vivo blocking of B7-H1 inhibited the protective effect of vaccination
He et al., Cancer Immunol Immunother 2005 (Adenocarcinoma...) : Low level of IFN-gamma upregulates expression of PD-L1 , PD-L2, CTLA-4 and Foxp3, which may partly account for the tumor immune evasion promoted by IFN-gamma
Tsuda et al., Biochem Biophys Res Commun 2005 : B7-H1 and B7-DC were also upregulated by stimulation with IFN-gamma , IL-13, and the supernatant from T cell clones
Chen et al., Int Immunopharmacol 2005 : Moreover, the significant damping effect of sinomenine on B7-H1 and B7-DC signals could promote IL-2 and IFN-gamma production by co-cultured CD4 ( + ) T cell
Kim et al., Am J Respir Cell Mol Biol 2005 : Expression of B7-H1 and B7-DC was selectively induced by stimulation of either BEAS2B or primary nasal epithelial cells ( PNEC ) with interferon (IFN)-gamma ( 100 ng/ml )
Yamazaki et al., J Immunol 2005 : These results indicated that the inhibition of T cell proliferation by anti-B7-H1 mAb was due to enhanced IFN-gamma production, which augmented NO production by macrophages, suggesting a critical role for B7-H1 on macrophages in regulating IFN-gamma production by naive CD4+ T cells and, hence, NO production by macrophages
Lee et al., J Dermatol Sci 2005 (Dermatitis...) : IFN-gamma regulates the expression of B7-H1 in dermal fibroblast cells
de Haij et al., Kidney Int 2005 : Stimulation with interferon-gamma (IFN-gamma) resulted in increased expression of B7-H1 , whereas ICOS-L expression was marginally increased upon stimulation with CD40L, with no effect of interleukin ( IL-1 ), IL-17, or tumor necrosis factor-alpha (TNF-alpha)
Kobayashi et al., J Rheumatol 2005 (Sjogren's Syndrome) : In vitro analysis using HSG cells revealed that PD-L1 was induced by interferon-gamma but not by tumor necrosis factor-alpha and IL-1beta
Stanciu et al., J Infect Dis 2006 (Respiratory Syncytial Virus Infections) : We used flow-cytometric analysis to investigate programmed death-1 ligand (PD-L) 1 , PD-L2, B7-H3, and inducible costimulatory ligand (ICOS-L) expression on tracheal ( NCI-H292 ), bronchial ( BEAS-2B ), and alveolar ( A549 ) epithelial cells ; regulation of this expression by RSV, interferon (IFN)- gamma , and interleukin (IL)-4 ; and the effects of IFN-gamma and IL-4 on RSV induced expression of these molecules
Lee et al., FEBS Lett 2006 : Interferon regulatory factor-1 is prerequisite to the constitutive expression and IFN-gamma induced upregulation of B7-H1 ( CD274 ) ... We addressed the molecular mechanism underlying the regulation of cancer associated B7-H1 expression in response to interferon-gamma (IFN-gamma) ... Electrophoretic mobility shift assay, site directed mutagenesis and knockdown experiment using siRNA revealed that interferon regulatory factor-1 (IRF-1) is primarily responsible for the constitutive B7-H1 expression as well as for the IFN-gamma mediated B7-H1 upregulation in a human lung cancer cell line A549 ... Our findings support a critical role of IRF-1 in the regulation of constitutive and IFN-gamma induced expression of B7-H1 in cancer cells
Mühlbauer et al., J Hepatol 2006 (Adenovirus Infections, Human) : PD-L1 is induced in hepatocytes by viral infection and by interferon-alpha and -gamma and mediates T cell apoptosis
Usui et al., Invest Ophthalmol Vis Sci 2006 (Retinal Neoplasms...) : B7H1 expression was induced by IFN-gamma stimulation and increased further when irradiated Y-79 cells were stimulated by IFN-gamma
Maier et al., J Immunol 2007 (Hepatitis B, Chronic) : These results indicate that PD-1 : PD-L1 interactions contribute to the suppression of IFN-gamma secretion observed following Ag recognition in the liver
Starke et al., Nephron. Experimental nephrology 2007 : TGF-beta treatment lead to a transition in morphology of renal TECs and downregulated the basal and the IFN-gamma stimulated PD-L1 expression in TECs
Grabie et al., Circulation 2007 (Inflammation...) : During cytotoxic T-lymphocyte induced myocarditis, the upregulation of PD-L1 on cardiac endothelia was dependent on T-cell derived interferon-gamma , and blocking of interferon-gamma signaling worsened disease
Seo et al., Immunology 2008 (Listeriosis) : B7-H1 blockade also suppressed the expression of granzyme B and interferon (IFN)-gamma by NK cells
Waeckerle-Men et al., Kidney Blood Press Res 2007 : Stimulation of TEC with IFN-beta or IFN-gamma , but not other tested cytokines, enhanced the expression of PD-L1 , ICOS-L and CD40
Dal Secco et al., Biol Reprod 2008 : We have found that, in response to interferon gamma (IFNG) , mouse Sertoli cells strongly up-regulate the negative co-stimulatory ligand B7-H1 but remain devoid of positive co-stimulatory molecules
Yang et al., Invest Ophthalmol Vis Sci 2008 (Melanoma...) : The results imply that the presence of IFN-gamma in the tumor local microenvironment promotes upregulation of PD-L1 expression by uveal melanoma, which may, in part, promote immune escape by impairing T-cell function
Liang et al., Cancer Lett 2008 (Breast Neoplasms) : In the present study, we demonstrated that triptolide was able to inhibit interferon-gamma induced PD-L1 surface expression in human breast cancer cells
Sheng et al., Cell Res 2008 : Using MSCs isolated from mouse bone marrow, we show here that interferon gamma (IFNgamma), a well-known proinflammatory cytokine produced by activated T cells, plays an important role in priming the immunosuppressive property of MSCs. Mechanistically, IFNgamma acts directly on MSCs and leads to up-regulation of B7-H1 , an inhibitory surface molecule in these stem cells
Wahl et al., Gastroenterology 2008 : In contrast, the PD-1/B7-H1 interaction inhibited proliferation and interferon-gamma release of effector/memory CD8 T blasts specifically restimulated by peptide pulsed HC
Boasso et al., Clin Immunol 2008 : HIV induced PDL-1 required interferon ( IFN ) -alpha, but not IFN-gamma , production
Kryczek et al., J Immunol 2008 : We show that IFN-gamma stimulates B7-H1 expression on APC subsets and abates their Th1 polarization capacity in a B7-H1 dependent manner ... We propose a novel dynamic between Th1 and Th17 in the course of inflammation as follows : Th1 mediated inflammation is attenuated by IFN-gamma induced B7-H1 on APCs and is evolved toward Th17 mediated chronic inflammation by IFN-gamma induced, APC derived IL-1 and IL-23
Liang et al., Cancer Lett 2009 (Breast Neoplasms) : We demonstrated that nimesulide was able to inhibit IFN-gamma induced PD-L1 surface expression in breast cancer cells
Wen et al., Transplantation 2008 (Diabetes Mellitus, Experimental) : In addition, NIT-PD-L1 suppressed interferon-gamma but up-regulated interleukin-4 and -10 productions by those lymphocytes in vitro and in vivo
Sugita et al., Invest Ophthalmol Vis Sci 2009 (Autoimmune Diseases...) : PD-L1 ( + ) RPE in the presence of IFNgamma selectively suppressed PD-1 ( + ) T-cell activation
Hong et al., Transplant Proc 2009 : The result suggested that IFN-gamma enhances expression of PDL-1 , MHC-I, MHC-II, and CD54 and boosts immunosuppressive ability in vivo
Phares et al., J Immunol 2009 (Coronavirus Infections...) : Infection of mice deficient in the IFN-gamma or IFN-alpha/beta receptor demonstrated that B7-H1 expression on oligodendroglia is predominantly regulated by IFN-gamma
Wu et al., Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2008 (Hepatitis B) : Whether or not transinfected with HBV, IFN-alpha and IFN-gamma both can induce the liver cell lines ( HepG2 cells and HepG2.2.15 cells ) PD-L1 expression while IL-4 can not ; IL-4, IFN-alpha, IFN-gamma all can induce the PD-L2 expression in HepG2.2.15 cells which was transinfected with HBV, only IFN-gamma can induce the PD-L2 expression in HepG2 cells which was not transinfected with HBV ... IFN-alpha, IFN-gamma both can induce the PD-L1 expression in HepG2 cells and HepG2.2.15 cells, while it is easy for cytokines to induce the PD-L2 expression in HepG2.2.15 cells which was transinfected with HBV, this may provide a potential mechanism of the molecular basis for chronic HBV infection
Rosignoli et al., Clin Exp Immunol 2009 (HIV Infections) : The effect of PD-1 and PD-L1 blockade on proliferation and interferon (IFN)-gamma production was tested on eight HIV-1 ( + ) patients
Okudaira et al., Int J Oncol 2009 (Adenocarcinoma...) : B7-H1 blockade increased the levels of IFN-gamma and FoxP3
Nagamatsu et al., Hum Reprod 2009 : B7-H1 blockade on DSCs strongly enhanced T cell cytokine production ( IFN-gamma , TNF-alpha and IL-2 ), whereas B7-DC blockade had similar but more modest effects
Kasagi et al., J Immunol 2010 (Nephritis) : Conversely, blocking PD-L1 using an anti-PD-L1 mAb increased the number of CD4 ( + ) PD-1 ( + ) T cells in the kidney, enhanced serum IFN-gamma , IL-10, and IgG2a ds-DNA-Ab levels, accelerated the nephritis, and increased the mortality rate
Avril et al., J Neuroimmunol 2010 (Glioblastoma) : PDL-1 partially affected the IFN-gamma production of antigen-specific T cells in response to GBM primary cell lines, and IDO inhibited lymphocyte proliferation induced by lectins