Gene interactions and pathways from curated databases and text-mining

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CASP6 — CDK4

Text-mined interactions from Literome

Sohn et al., Cancer Res 2006 : p21 blocks irradiation induced apoptosis downstream of mitochondria by inhibition of cyclin dependent kinase mediated caspase-9 activation
Yang et al., Mol Med Report 2010 : The expression of cyclin D1 , cyclin dependent kinase 4 (CDK4), Bcl-2, Bcl-xL and the activation of caspase-3 were examined by Western blotting
Shirali et al., Tumour Biol 2013 (Ovarian Neoplasms) : The results of this study suggest that extracellular adenosine induced G1 cell cycle arrest and apoptosis in ovarian cancer cells via cyclinD1/ Cdk4 and Bcl-2/Bax pathways and caspase-3 activation