Gene interactions and pathways from curated databases and text-mining

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CIITA — CREB1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

van der Stoep et al., J Immunol 2002 : Transcriptional regulation of the MHC class II trans-activator ( CIITA ) promoter III : identification of a novel regulatory region in the 5'-untranslated region and an important role for cAMP-responsive element binding protein 1 and activating transcription factor-1 in CIITA-promoter III transcriptional activation in B lymphocytes ... A similar successive deletion of the CREs resulted in a subsequent reduction of CREB-1 induced activity of CIITA-PIII in B cells
Kwon et al., J Immunol 2006 : The decrease of CIITA gene expression in the presence of the PKCdelta inhibitor was prevented by ectopically expressing a constitutively active form of CREB