Gene interactions and pathways from curated databases and text-mining

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CREB3 — MTOR

Text-mined interactions from Literome

Ohmae et al., J Biol Chem 2006 : Although these were previously shown to activate Ca ( 2+ ) /cAMP-response element binding protein ( CREB ) -dependent transcription, we here show that CL1 and CL2 were unable to significantly phosphorylate CREB Ser-133 and rather inhibited CRE dependent gene expression by a dominant mechanism that bypassed CREB and was mediated by phosphorylated TORC2
Palaniappan et al., Mol Endocrinol 2012 : Furthermore, the pharmacological inhibition of mTORC1 or ribosomal protein S6 kinase 1 signaling prevented the LH/hCG induced phosphorylation of CREB
Wang et al., J Immunol 2011 (Inflammation) : At the transcriptional level, mTORC1 inhibition reduced the DNA binding of CREB and this effect was reversed by GSK3 inhibition
Zhong et al., PloS one 2012 (Inflammation...) : This study indicates that resveratrol inhibited LPS induced proinflammatory enzymes and proinflammatory cytokines via down-regulation phosphorylation of NF-?B, CREB and MAPKs family in a mTOR dependent manner