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E2F1 — PARP6

Text-mined interactions from Literome

Simbulan-Rosenthal et al., Oncogene 1999 : To examine the role of PARP in the regulation of pol alpha and E2F-1 gene expression, we utilized immortalized mouse fibroblasts derived from wild-type and PARP knockout ( PARP-/- ) mice as well as PARP-/- cells stably transfected with PARP cDNA [ PARP-/- ( +PARP ) ] ... To investigate the effect of PARP on E2F-1 promoter activity, a construct containing the E2F-1 gene promoter fused to a luciferase reporter gene was transiently transfected into these cells ... These results suggest that PARP plays a role in the induction of E2F-1 promoter activity, which then positively regulates both E2F-1 and pol alpha expression, when quiescent cells reenter the cell cycle upon recovery from aphidicolin exposure or removal of serum
Simbulan-Rosenthal et al., Biochemistry 1998 : Depletion of PARP also prevented induction of the expression of the transcription factor E2F-1 , which positively regulates transcription of the DNA pol alpha and PCNA genes ; thus, PARP may be necessary for expression of these genes when quiescent cells are stimulated to proliferate