Gene interactions and pathways from curated databases and text-mining

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CASP7 — EGF

Text-mined interactions from Literome

Gibson et al., J Biol Chem 1999 : EGF stimulation of epithelial cells also inhibited Fas induced caspase activation and the proteolysis of signaling proteins downstream of the EGF receptor, Cbl and Akt/protein kinase B ( Akt )
De Smet et al., Biochem Pharmacol 2001 : Effects of epidermal growth factor on CYP inducibility by xenobiotics, DNA replication, and caspase activations in collagen I gel sandwich cultures of rat hepatocytes ... In collagen gel sandwich cultures, we found that neither collagen I nor EGF prevented activation of caspase 8 while collagen I gel inhibited activation of caspase 3, preventing spontaneous apoptosis of cultured rat hepatocytes ... In contrast, EGF transiently increased caspase 3 activity at day 1 after plating
Cenni et al., Cancer Chemother Pharmacol 2001 (Ovarian Neoplasms) : The EGF mediated increase in cisplatin induced apoptosis, however, did not result in increased caspase 3 activity
Takeuchi et al., J Biol Chem 2004 : Furthermore, ADR induced activation of caspase-9 , a downstream molecule of Akt, was inhibited for at least 24 h after HGF/SF stimulation, but it was not affected by EGF stimulation
Chiu et al., J Pediatr Surg 2007 (Neuroblastoma) : We previously reported that epidermal growth factor (EGF) induced cleaved caspase 3 expression and apoptosis in human neuroblastoma cells ... We hypothesized that EGF upregulates total caspase 3 expression, thereby enhancing the cytotoxic potency of chemotherapeutic agents ... Cells incubated with EGF ( 5 ng/mL ) for 24 hours before doxorubicin treatment were used to determine the effect of EGF on cell replication and cleaved caspase 3 expression
Senft et al., Cancer Res 2007 (Carcinoma, Squamous Cell) : Stimulation of motility with epidermal growth factor induced the phosphorylation of caspase-8 on tyrosine-380 and the interaction of caspase-8 with the p85 alpha subunit of phosphatidylinositol 3-kinase
Ge et al., Biol Reprod 2009 : On the other hand, inhibition of EGFR, Ca ( 2+ ) /PKC, or NFKB1 abolished the EGF stimulated increase in the expression of cyclins CCND1 and CCNE1, cyclin dependent kinase 6 (CDK6), CDK2, and BCL2, and restored the EGF induced inhibition of BAX expression and caspase 3/9 activity, indicating that EGFR, PKC, and NFKB1 signaling cascades were involved in EGF stimulated DNA synthesis and antiapoptosis action
Song et al., Cancer Lett 2009 : EGF induced death signaling is apparently irreversible : EGF induced significant EGFR phosphorylation/internalization and activated caspase-3 , -8 and -9, effects that were not observed in cetuximab- or gefitinib treated cells
Ji et al., Environ Toxicol 2010 : In this study, we found that EGF ( 1 ng/mL ) inhibited clivorine induced antiapoptotic Bcl-xL protein decrease, caspase-9 activation, and release of cytosolic cytochrome C
Finlay et al., Cancer Res 2009 : Caspase-8 null cells and cells reconstituted with caspase-8 harboring point mutations of these critical amino acids also show defective EGF induced migration as compared with cells reconstituted with the wild-type protein
Peng et al., J Biol Chem 2011 : In addition, we showed that EGF induces caspase-8 ubiquitination and degradation through the proteasome pathway, and phosphorylation of Thr-263 is associated with caspase-8 stability
Yang et al., Biochem Pharmacol 2011 (Liver Neoplasms) : In fenretinide sensitive Huh7 cells, activation of ERK1/2 by epidermal growth factor (EGF) prevented fenretinide induced cell death and caspase 3/7 induction
Chin et al., Mol Cell Biol 1997 : We further demonstrated that both EGF and IFN-gamma induced caspase 1 ( interleukin-1beta converting enzyme [ ICE ] ) gene expression in a STAT dependent manner