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EGR1 — EPHB2

Text-mined interactions from Literome

Deguchi et al., Circ Res 1999 : In adult rat VSMCs, Ang II activates ERK and JNK, but weakly induces Egr-1 , a transcription factor implicated in PDGF-B chain gene expression, compared with newborn VSMCs
Harada et al., Nat Cell Biol 2001 : ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1
Lo et al., J Cell Physiol 2001 : Involvement of PKCalpha in mediating ERK activation was further confirmed by the inhibition of ERK and the subsequent Egr-1 gene induction with antisense oligonucleotides to PKCalpha
Guillemot et al., J Biol Chem 2001 (MAP Kinase Signaling System) : Taken together, these findings demonstrate that Ang II-induced cyclin D1 up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region, both in a p21(ras)/Raf-1/MEK/ERK dependent manner, and also involves PI3K and SHP-2
Sakaue et al., Cell Death Differ 2001 (Carcinoma...) : Induction of Egr-1 expression by the retinoid AHPN in human lung carcinoma cells is dependent on activated ERK1/2 ... Our results suggest that the induction of Egr-1 in H460 by AHPN requires active ERK1/2 and is independent of p38 activation
Zhang et al., J Biol Chem 2001 (Calcium Signaling) : Egr-1/MGRE binding was induced by GnRH in an ERK dependent manner
Kaufmann et al., J Cell Biochem 2002 (MAP Kinase Signaling System) : Proliferation, activation of ERK , and biosynthesis of Egr-1 was completely inhibited in EGF or thrombin treated HaCaT cells by the MAP kinase kinase inhibitor PD98059 and by AG1487, an EGF receptor-specific tyrosine kinase inhibitor
Shi et al., Am J Physiol Cell Physiol 2002 : Using a chloramphenicol acetyltransferase reporter gene linked to the Egr-1 promoter, we show that LPS increased Egr-1 promoter activity via an ERK1/2 dependent mechanism ... These results delineate the role of ERK1/2 activation of Egr-1 activity in mediating LPS induced increases in TNF-alpha mRNA expression in macrophages
Brummer et al., EMBO J 2002 : The Raf-1/B-Raf double deficient DT40 cells show an almost complete block both in ERK activation and in the induction of the immediate early gene products c-Fos and Egr-1
Fujino et al., J Biol Chem 2003 (MAP Kinase Signaling System) : Furthermore, this activation of PI3K/ERK signaling by the EP ( 4 ) receptors induces the functional expression of early growth response factor-1 (EGR-1)
Rolli-Derkinderen et al., J Biol Chem 2003 : PMA and granulocyte/macrophage colony stimulating factor induce Egr-1 expression through ERK and p38 activation, respectively
Osawa et al., J Biol Chem 2004 : To investigate whether Gab1-ERK1/2 interaction is critical for ERK1/2 and Egr-1 nuclear accumulation, we created a dominant negative Gab1 construct that consisted of the c-Met binding domain ( amino acids 442-536 ) of Gab1 ... We found that overexpression of the c-Met binding domain of Gab1 disrupted serum induced Gab1-ERK1 interaction and inhibited ERK1 and Egr-1 nuclear accumulation ... These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 nuclear accumulation
Fujita et al., J Clin Invest 2004 (Ischemia...) : In vitro, hypoxia/reoxygenation mediated induction of Egr-1 in MPs was suppressed by inhibition of PKCbeta, ERK1/2 , and JNK, but not by inhibition of p38 MAPK
Wei et al., J Biol Chem 2004 (Second Messenger Systems) : G-protein mediated ERK activation enhanced the transcription of early growth response 1 , whereas beta-arrestin 2-dependent ERK activation did not
Bauer et al., Arch Biochem Biophys 2005 (Carcinoma, Hepatocellular) : Activation of extracellular signal regulated protein kinase ( ERK ) triggers the biosynthesis of Egr-1 , a zinc finger transcription factor ... Here, we have analyzed the genetic elements involved in the regulation of Egr-1 gene transcription by ERK and TPA in human hepatoma cells
Mishra et al., Proc Natl Acad Sci U S A 2006 (Anoxia...) : In RAW macrophages in vitro, hypoxia induced Egr-1 mRNA expression was ERK dependent, and CO-mediated suppression of ERK activation resulted in Egr-1 inhibition
Zuo et al., Eur J Pharmacol 2006 (Hypoxia-Ischemia, Brain...) : The increased expression of Egr-1 and Bcl-2 by isoflurane was inhibited by ERK inhibition
Ke et al., J Biol Chem 2006 (Lymphoma, B-Cell...) : Inhibitors of ERK and JNK ( but not of p38 MAPK ) reduced egr-1 expression at the protein level
Stefano et al., J Cell Physiol 2007 (MAP Kinase Signaling System) : These results indicate that phosphorylation and activation of extracellular signal regulated protein kinase ERK , elevated levels of intracellular Ca ( 2+ ) and the transactivation of the EGF receptor are essential for BzATP induced upregulation of Egr-1
Li et al., Am J Physiol Lung Cell Mol Physiol 2007 : Further investigation showed that CSE could also stimulate early growth response-1 (EGR-1) in an ERK dependent manner and that the expression of HSP70 was EGR-1 dependent
Wenzel et al., Biol Chem 2007 (Breast Neoplasms...) : We further show that the up-regulation of EGR1 in MCF7/KEPI cells is mediated by MEK-ERK signaling
Park et al., J Biol Chem 2007 : Inhibition of ERK1/2 with U0126 potently suppressed gAcrp stimulated Egr-1 promoter activity, as well as TNF-alpha promoter activity
De Croos et al., Osteoarthritis Cartilage 2007 : These data suggest that cyclic compression of chondrocytes in vitro upregulates MT1-MMP via ERK1/2 dependent activation of Egr-1 binding
Moon et al., Biochem Biophys Res Commun 2007 : DON activated ERK1/2 also mediated the production of early growth response gene 1 (EGR-1) in the epithelial cell line and EGR-1 had the positive regulatory effect on the interleukin-8 production in the human epithelial cells
Kim et al., J Cell Biochem 2008 : The siRNA mediated inhibition of PKA and ERK1 resulted in significant reduction of EX-4 induced Egr-1 expression
Beidelschies et al., J Cell Physiol 2008 : Moreover, ERK1/2 activation by wear particles is also required for increased expression of the transcription factor Egr-1 as well as Egr-1 's ability to bind to and activate the TNFalpha promoter
Hao et al., J Biol Chem 2008 (Atherosclerosis...) : Using specific pharmacological inhibitors and small interfering RNA technology, we determined that PKCdelta and ERK , but not p38 and JNK, mediate histamine induced Egr-1 expression
Lin et al., Cell Signal 2009 : Through inhibitor assays, we have further shown that MEK-ERK1/2 is required for FGF1 induced neurite outgrowth, pSTAT3 ( S727 ) and Egr1 expression
Bliss et al., Mol Endocrinol 2009 : The effects of ERK pathway ablation on LH biosynthesis underlie this gender-specific phenotype, and the molecular mechanism involves a requirement for ERK dependent up-regulation of the transcription factor Egr1 , which is necessary for LHbeta expression
Abdel-Latif et al., J Cell Biochem 2009 : High content analysis of Egr-1 activation showed acid induced Egr-1 nuclear translocation ; a maximum observed at 1-2 h followed by a decline to basal levels beyond 4 h. Acidic pH also activated ERK1/2 phosphorylation, whereas ERK1/2 inhibitors PD98059 and U0216 blocked both acid induced Egr-1 and ERK translocation and expression
Ramana et al., Mol Immunol 2009 (Lung Diseases) : We further demonstrate that Egr-1 induction is triggered by TNF-alpha dependent ERK activation, and inhibition of this pathway ablates Egr-1 expression
Shin et al., Exp Mol Med 2010 (Glioma) : Further analysis showed that the ERK and JNK MAP kinases are required for induction of Egr-1 by CPZ
Gorina et al., Glia 2011 : p38 exerted a strong influence on LPS induced gene expression by regulating the phosphorylation of Stat1 and the transcriptional activity of NF?B, while JNK regulated the Jak1/Stat1 pathway, and ERK1/2 controlled the expression of Egr-1 and influenced MyD88 dependent MMP-9 expression
Shen et al., Am J Pathol 2011 (Pulmonary Disease, Chronic Obstructive) : The accumulation of EGR-1 and GGPPS was induced by MAPK/ERK pathway activation when Beas-2B human bronchial epithelial cells were exposed to cigarette smoke extract (CSE)
Shen et al., J Biol Chem 2011 (Diabetes Mellitus, Type 2...) : In this report, we found that chronic exposure to hyperinsulinism caused persistent Erk/MAPK activity in adipocytes and enhanced insulin resistance in an Egr-1 dependent manner
Chbicheb et al., Biochem Pharmacol 2011 (Breast Neoplasms) : EGR1 mRNA induction required ERK1/2 phosphorylation which was not blocked by EGF Receptor (EGFR) inhibition ... Using the fluorescent dye Fura2, we showed in MCF7 that TGZ or d2-TGZ induced an immediate increase in cytosolic calcium which was required for ERK1/2 phosphorylation and EGR1 mRNA induction as demonstrated by calcium chelation experiments
Iyoda et al., J Biol Chem 2012 (MAP Kinase Signaling System) : Our data demonstrate that activation of ERK1/2 and JNK, but not p38 MAPK, is required for LPA induced Egr-1 expression in smooth muscle cells
Li et al., J Basic Microbiol 2013 : The ERK1/2-specific inhibitor significantly blocked the increased expression in Egr-1 and PCNA induced by coccoid H. pylori
Lin et al., PloS one 2013 (Hyperglycemia...) : EGR-1 siRNA also reduced GDNF/EGR-1 induced cRaf/MEK/ERK phosphorylation by 80 %
Ha et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2013 : Finally, ERK1/2 signaling regulated Egr-1 protein expression and treatment with recombinant CTGF reversed the Egr-1 expression in high glucose induced VSMCs
Cohen et al., Proc Natl Acad Sci U S A 1996 : Urea-inducible Egr-1 transcription was a consequence of ERK activation because the ERK-specific inhibitor, PD98059, abrogated transcription from the murine Egr-1 promoter in a luciferase reported gene assay
Brüning et al., Mol Cell Biol 1997 : These results indicate that IRS-1 is not necessary for activation of ERK 1 and ERK 2 and that activation of ERK 1 and ERK 2 is not sufficient for IGF-1 stimulated activation of c-fos and egr-1