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EIF2AK2 — TNF
Text-mined interactions from Literome
Bandyopadhyay et al., J Immunol 2000
:
Induction of E-selectin promoter activity and NF-kappaB DNA binding activity were substantially reduced in pIC- or TNF-alpha treated PKR-null cells, indicating a
role for
PKR in both pIC and
TNF-alpha induction of E-selectin via an NF-kappaB dependent pathway ... These results indicate that the
PKR is
required for full activation of E-selectin expression by pIC and
TNF-alpha in primary mouse aortic endothelial cells identifying activating transcription factor 2 as a new target for PKR dependent regulation and suggest a role for PKR in leukocyte adhesion
von Holzen et al., Surgery 2005
(Adenocarcinoma...) :
Inhibition of
TNF-alpha expression by tetracycline
resulted in downregulation of
PKR and decreased apoptosis
Scheuner et al., J Biol Chem 2006
:
TNFalpha treatment
induced eIF2alpha phosphorylation and activation of caspase 3 primarily through the dsRNA activated eIF2alpha kinase
PKR
Bennett et al., Blood 2006
(Inflammation...) :
Thus, knock-down of RAX expression by 80 % using small interfering RNA ( siRNA ) prevents
IFNgamma/tumor necrosis factor alpha (TNFalpha) induced
PKR activation and eIF2alpha phosphorylation, IkappaB degradation, IRF-1 expression, and STAT1 phosphorylation, resulting in enhanced murine embryonic fibroblast (MEF) cell survival
Takada et al., Oncogene 2007
:
Overall, our results indicate that
PKR differentially
regulates TNF signaling ; IKK, Akt and JNK were positively regulated, whereas p44/p42 MAPK and p38 MAPK were negatively regulated
Myskiw et al., J Virol 2009
:
PKR dependent activation of p38 and NF-kappaB was required for vaccinia virus induced INHBA expression, whereas induction of
TNF-alpha required only
PKR dependent NF-kappaB activation
Yeung et al., J Biol Chem 1998
:
This p53 induction lags behind the
TNF-alpha induction of
PKR by 1 h ... This latter result indicates that p53 induction is an event downstream of
TNF-alpha induced up-regulation of
PKR , thereby further establishing the critical role of p53 in TNF-alpha induced apoptosis in U937 cells