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EGF — EIF4EBP1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
EIF4EBP1
→
EGF
(increases)
Olsen et al., Cell 2006*
Evidence: We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database
Text-mined interactions from Literome
Galbaugh et al., BMC cell biology 2006
:
The activation of p70S6K by insulin or
EGF resulted in the phosphorylation of ribosomal protein S6 (RPS6), elongation initiation factor 4E ( elF4E ) and
4E binding protein1 (4E-BP1)
Cao et al., Science signaling 2009
:
Loss of Galpha ( i1 ) and Galpha ( i3 ) severely impaired the activation of Akt and of p70 S6 kinase and
4E-BP1 , downstream targets of mTORC1, in
response to
EGF , heparin binding EGF-like growth factor, and transforming growth factor alpha, but not insulin, insulin-like growth factor, or platelet derived growth factor
Diggle et al., Biochem J 1996
:
This study compares the
effects of insulin and
epidermal growth factor (EGF) on the phosphorylation of
4E-BP1 in fat-cells ( followed by gel-shift assays and incorporation of 32P ) and on its association with eIF-4E
Kleijn et al., FEBS Lett 1996
:
Both
EGF and NGF
induced phosphorylation of
PHAS-I ... This excludes a role for MAPK in NGF- and
EGF induced
PHAS-I phosphorylation in PC12 cells