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ERBB2 — MAPK6
Text-mined interactions from Literome
Badache et al., Cancer Res 2001
(Breast Neoplasms...) :
Down-regulation of ErbB receptor activity, through the use of specific pharmacological inhibitors or dominant negative receptor constructs, revealed that IL-6 induced
MAPK activation was largely
dependent on epidermal growth factor (EGF) receptor activity, but not on
ErbB-2 activity
Deb et al., J Biol Chem 2001
:
The kinase activity, but not tyrosine phosphorylation, of
ErbB2 was
required for EGF induced
MAPK activation
Bowers et al., Oncogene 2001
(Breast Neoplasms...) :
Inhibiting
ErbB2 caused an enhanced
MAPK response simulating an amplified ErbB1 ( or 4 ) response
Kiguchi et al., Cancer Res 2001
(Adenocarcinoma...) :
Increased
ErbB-2/epidermal growth factor receptor heterodimer formation,
activation of
mitogen activated protein kinase , and up-regulation of cyclooxygenase-2 levels ( mRNA and protein ) were observed in gallbladder epithelium of these mice
Vijapurkar et al., Exp Cell Res 2003
(Cell Transformation, Neoplastic...) :
Roles of
mitogen activated protein kinase and phosphoinositide 3'-kinase in
ErbB2/ErbB3 coreceptor mediated heregulin signaling
Lu et al., Biochem Biophys Res Commun 2004
(Breast Neoplasms...) :
We report that the overexpression of
ErbB2 inhibits IGF-I induced
MAPK signaling ... In SKBR3/IGF-IR cells, reduction of
ErbB2 by antisense methodology
restores the IGF-I induced
MAPK activation
Benlimame et al., J Cell Biol 2005
(Cell Transformation, Neoplastic...) :
ErbB induced oncogenic transformation correlates with the ability of FAK to restore
ErbB-2/3 induced
mitogen activated protein kinase ( MAPK ) activation ; the inhibition of MAPK prevented oncogenic transformation
Gunawardane et al., Cancer Res 2005
(Breast Neoplasms...) :
Constitutive activation of the extracellular signal regulated kinase ( ERK ) pathway also enhanced PDEF induced motility and invasion, suggesting that
activation of the
ERK/mitogen activated protein kinase by
ErbB2 and CSF-1R/CSF-1 can cooperate with PDEF to promote motility and invasion
Fan et al., J Biol Chem 2008
:
Expression of the activated
ErbB2 mutants in cells
resulted in elevated ligand independent ErbB2 autophosphorylation, ErbB3 phosphorylation, and stimulation of
mitogen activated protein kinase
Xiang et al., Proc Natl Acad Sci U S A 2008
(Breast Neoplasms...) :
Expression of Brk enhances the
ErbB2 induced activation of
Ras/MAPK signaling and cyclin E/cdk2 activity to induce cell proliferation of mammary 3-dimensional acini in culture
Kim et al., Cancer Lett 2009
(MAP Kinase Signaling System...) :
Overexpression of
ErbB2 significantly
activated p38
MAPK and Akt, while Raf-1/MEK/ERK pathway was not activated by ErbB2
Zhou et al., Zhonghua Yi Xue Za Zhi 2012
(MAP Kinase Signaling System) :
After a pretreatment of antibodies of
ErbB2 , ErbB3,
inhibitors of
p38MAPK , ERK1/2, MSK1 and antibody of CREB and a stimulation of NRG-1ß, the expression of MUC5AC decreased ( 0.221 ± 0.033, 0.238 ± 0.044, 0.386 ± 0.021, 0.352 ± 0.022, 0.294 ± 0.017, 0.252 ± 0.019 ) versus the NRG-1ß group ( 0.650 ± 0.134 )
Marte et al., Oncogene 1995
:
Activation of
ErbB-2 by point mutation, or by monoclonal antibodies, also
stimulates both the
MAPK and the p70/p85 S6 kinase pathways