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E2F1 — EZH2

Text-mined interactions from Literome

Wu et al., Cell Death Differ 2010 : We show that E2F1 induces EZH2 expression, which in turn antagonizes the induction of E2F1 pro-apoptotic target Bim expression ... Hence, the concomitant induction of EZH2 and Bim by E2F1 constitutes a fail-safe mechanism to allow tumor cells with aberrant E2F1 activity to evade apoptosis
Duan et al., Prostate 2013 (Prostatic Neoplasms) : While androgen suppresses EZH2 in CRPC cells, in LNCaP cells, physiological concentrations of androgen stimulate expression of PRC2 genes ( EZH2, SUZ12, and EED ), which is mediated by androgen induced ANCCA and involves E2F and histone H3K4me3 methylase MLL1 complex