Gene interactions and pathways from curated databases and text-mining

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F2R — IL6

Text-mined interactions from Literome

Gordon et al., Cell Immunol 2000 : Thrombin induces IL-6 but not TNFalpha secretion by mouse mast cells : threshold-level thrombin receptor and very low level FcepsilonRI signaling synergistically enhance IL-6 secretion
Asokananthan et al., J Immunol 2002 : PAR-1 , PAR-2, or PAR-4, in combination, caused additive IL-6 release, but only the PAR-1 and PAR-2 combination resulted in an additive IL-8 response
Lang et al., Invest Ophthalmol Vis Sci 2003 : HCE-T expression of cytokines ( IL-6 , IL-8, and TNFalpha ) in response to activation of PAR-1 and -2 was measured by quantitative RT-PCR and ELISA
Scholz et al., Int J Mol Med 2004 (Cytomegalovirus Infections) : Thrombin/PAR-1 mediated signaling stimulated PKC and NF-kappaB dependent IL-6 and IL-8 gene expression via phosphoinositide 3-kinase and further downstream via p42/44 and p38 MAPKs ... Thus, thrombin/PAR-1 mediated IL-6/IL-8 gene expression is uncoupled from Sp1 inhibition and may support proinflammatory pathomechanisms probably involved in hemorrhage/HCMV retinitis progression
Li et al., Immunol Cell Biol 2006 (Inflammation) : Induction of IL-6 release from human T cells by PAR-1 and PAR-2 agonists
Chiu et al., Mol Immunol 2008 : Thrombin induced IL-6 production in human synovial fibroblasts is mediated by PAR1 , phospholipase C, protein kinase C alpha, c-Src, NF-kappa B and p300 pathway ... By using pharmacological inhibitors or activators or genetic inhibition by the protease activated receptor (PAR), siRNA revealed that the PAR1 receptor but not other PAR receptors is involved in thrombin mediated up-regulation of IL-6
Cooper et al., PloS one 2011 (Inflammation) : Through the use of PAR-1 and PAR-2 neutralizing antibodies, it was determined that PAR-1 is essential for GrK induced IL-6 , IL-8 and MCP-1 release
Nieuwenhuizen et al., Scand J Immunol 2013 : In contrast, stimulation of PBMCs with coagulation proteases resulted in thrombin mediated induction of IL-1ß and IL-6 cytokine production and PBMC cell proliferation in a PAR-1 dependent manner