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FGF2 — HIF1A
Text-mined interactions from Literome
Fang et al., Cancer Res 2001
(Chondrosarcoma...) :
This study implicates
HIF-1alpha mediated up-regulation of VEGF but not
bFGF in the switch to the angiogenic phenotype during tumorigenesis
Shi et al., Zhonghua Yi Xue Za Zhi 2004
(Breast Neoplasms) :
SU5402 and LY294002 100 % inhibited the
bFGF induced expression of
HIF-1alpha protein
Shi et al., J Pathol 2005
(Breast Neoplasms) :
The data show that
HIF-1alpha expression is
induced by
bFGF in a dose- and time dependent fashion, while increased HIF-1alpha protein expression and transactivity of HIF-1 are due to the phosphorylation of Akt by bFGF, as indicated by application of the phosphatidylinositol 3-kinase (PI-3K) inhibitor LY294002 ... The data also show that the MEK1 ( mitogen activated protein kinase kinase-1 ) /ERK ( extracellular signal regulated kinase ) pathway is only involved in
bFGF induced transactivity of HIF-1, but not
HIF-1alpha expression, indicating roles for both the PI-3K/Akt and the MEK1/ERK pathways in bFGF activity ... In addition, the translation inhibitor cycloheximide confirmed that
bFGF induced
HIF-1alpha protein expression was due to de novo protein synthesis
Calvani et al., Blood 2006
:
Notably,
bFGF dependent induction of cord formation under normoxic conditions
required HIF-1alpha activity, which was also essential for hypoxic induction of bFGF mRNA and protein expression
Dai et al., Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2007
:
PcDNA-HIF1alpha can stably transfected into fibroblasts cells, and the expressed HIF-1alpha
induces the expression of VEGF and
bFGF , and the expressed VEGF enhances the activity of cells
Shi et al., Pathology 2007
(Breast Neoplasms...) :
Basic
FGF augments hypoxia
induced HIF-1-alpha expression and VEGF release in T47D breast cancer cells
Black et al., Am J Physiol Cell Physiol 2008
:
Stabilization of
HIF-1alpha increased
FGF-2 promoter activity, whereas mutation of the putative HRE attenuated FGF-2 induced FGF-2 promoter activity ... Furthermore,
FGF-2 increased
HIF-1alpha protein levels and consensus HRE promoter activity in PASMC via antioxidant-sensitive mechanisms
Conte et al., PloS one 2008
:
These data reveal the physiological importance of IRES dependent translation during hypoxic stress and underline the complexity of the cellular response to hypoxia, suggesting a novel
role of
FGF2 in the regulation of
HIF-1alpha during the induction of angiogenesis