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FGF2 — HIF1A

Text-mined interactions from Literome

Fang et al., Cancer Res 2001 (Chondrosarcoma...) : This study implicates HIF-1alpha mediated up-regulation of VEGF but not bFGF in the switch to the angiogenic phenotype during tumorigenesis
Shi et al., Zhonghua Yi Xue Za Zhi 2004 (Breast Neoplasms) : SU5402 and LY294002 100 % inhibited the bFGF induced expression of HIF-1alpha protein
Shi et al., J Pathol 2005 (Breast Neoplasms) : The data show that HIF-1alpha expression is induced by bFGF in a dose- and time dependent fashion, while increased HIF-1alpha protein expression and transactivity of HIF-1 are due to the phosphorylation of Akt by bFGF, as indicated by application of the phosphatidylinositol 3-kinase (PI-3K) inhibitor LY294002 ... The data also show that the MEK1 ( mitogen activated protein kinase kinase-1 ) /ERK ( extracellular signal regulated kinase ) pathway is only involved in bFGF induced transactivity of HIF-1, but not HIF-1alpha expression, indicating roles for both the PI-3K/Akt and the MEK1/ERK pathways in bFGF activity ... In addition, the translation inhibitor cycloheximide confirmed that bFGF induced HIF-1alpha protein expression was due to de novo protein synthesis
Calvani et al., Blood 2006 : Notably, bFGF dependent induction of cord formation under normoxic conditions required HIF-1alpha activity, which was also essential for hypoxic induction of bFGF mRNA and protein expression
Dai et al., Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2007 : PcDNA-HIF1alpha can stably transfected into fibroblasts cells, and the expressed HIF-1alpha induces the expression of VEGF and bFGF , and the expressed VEGF enhances the activity of cells
Shi et al., Pathology 2007 (Breast Neoplasms...) : Basic FGF augments hypoxia induced HIF-1-alpha expression and VEGF release in T47D breast cancer cells
Black et al., Am J Physiol Cell Physiol 2008 : Stabilization of HIF-1alpha increased FGF-2 promoter activity, whereas mutation of the putative HRE attenuated FGF-2 induced FGF-2 promoter activity ... Furthermore, FGF-2 increased HIF-1alpha protein levels and consensus HRE promoter activity in PASMC via antioxidant-sensitive mechanisms
Conte et al., PloS one 2008 : These data reveal the physiological importance of IRES dependent translation during hypoxic stress and underline the complexity of the cellular response to hypoxia, suggesting a novel role of FGF2 in the regulation of HIF-1alpha during the induction of angiogenesis