Gene interactions and pathways from curated databases and text-mining

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FOS — MAPK1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Medvedev et al., J Biol Chem 1999 : Lipopolysaccharide and ceramide mimetics showed distinct kinetics of mitogen activated protein kinase phosphorylation and AP-1 induction and activated AP-1 complexes with different subunit compositions
Kim et al., J Gen Virol 1999 : IE1-driven activation of AP-1 was increased dramatically by mitogen activated protein kinase/extracellular signal regulated kinase kinase kinase 1 ( MEKK1 )
Cho et al., Free Radic Biol Med 1999 : The MAPK activity stimulated by ROS may be involved in the activation of AP-1
Balmanno et al., Oncogene 1999 : The expression of c-Fos , Fra-1 and JunB was dependent upon the activation of MAPK since these responses were inhibited by PD098059
Nandan et al., Infect Immun 1999 : Activation of phosphotyrosine phosphatase activity attenuates mitogen activated protein kinase signaling and inhibits c-FOS and nitric oxide synthase expression in macrophages infected with Leishmania donovani
Shimizu et al., Cardiovasc Res 1999 : The c-fos induction, the increased AP-1 binding activity and the acceleration of DNA synthesis were all attenuated by genistein ( 100 microM ) or MAPK kinase inhibitor ( 10 or 50 microM PD98059 )
Armelin et al., Braz J Med Biol Res 1999 (Adrenal Cortex Neoplasms...) : ACTH, itself a very weak mitogen, blocks the mitogenic response effect of FGF2 in the early and middle G1 phase, keeping both ERK-MAPK activation and c-Fos induction at maximal levels
Nunomura et al., J Immunol 2000 : In response to stimulation, a marked induction of c-Fos protein expression as well as cell proliferation is detected only in CD4+8- single positive cells but not in selected and nonselected DP cells, though mitogen activated protein kinase activities and c-fos transcripts are equally induced
Lotfi et al., Braz J Med Biol Res 2000 (Adrenal Cortex Neoplasms) : FGF2 elicits a strong mitogenic response in G0/G1 arrested Y1 adrenocortical cells, that includes a ) rapid and transient activation of extracellular signal regulated kinases-mitogen activated protein kinases ( ERK-MAPK) (2 to 10 min ), b ) transcription activation of c-fos, c-jun and c-myc genes ( 10 to 30 min ), c ) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by 5 h, and d ) onset of DNA synthesis stimulation within 8 h. ACTH, itself a weak mitogen, interacts with FGF2 in a complex manner, blocking the FGF2 mitogenic response during the early and middle G1 phase, keeping ERK-MAPK activation and c-Fos and cyclin D1 induction at maximal levels, but post-transcriptionally inhibiting c-Myc expression
Lepique et al., Endocr Res 2000 : In G0/G1 cell cycle arrested mouse Y1 adrenocortical tumor cells ACTH39, a weak mitogen and strong anti-mitogenic agent, blocks FGF2 mitogenic activity at G1 phase, keeping untouched ERK-MAPK activation and c-Fos protein induction
Acquaah-Mensah et al., Toxicol Appl Pharmacol 2001 : Thus this acute ethanol induced increased AP-1 transcriptional activation requires protein synthesis and involves MEK independent increased MAPK phosphorylation, on the one hand, and decreased SAPK-1 activity on the other
Wilmer et al., Kidney Int 2001 : This current study investigated the mechanisms of HG-mediated activation of p38 MAPK in cultured human mesangial cells ( HMCs ) and the effects of p38 MAPK activation on the transcription factor activator protein-1 (AP-1)
Oh et al., J Biol Chem 2001 : This Lf-induced AP-1 DNA binding activity was reduced by a p38 MAPK inhibitor
Hirokawa et al., Dig Dis Sci 2001 : The expression of early immediate genes, MAPK activity, and activation of nuclear factor activator protein-1 (AP-1) were also examined ... Early inductions of c-myc and c-fos proteins, increased activity of MAPK , and activation of AP-1 were observed by pressure loading
Mendes et al., Nitric Oxide 2002 : Finally, the p42/44MAPK inhibitor, PD 98059, prevented IL-1 induced AP-1 activation in a concentration that did not inhibit iNOS expression
Granet et al., Cell Signal 2002 : Downregulation of protein kinase C ( PKC ) and COX1/2 or inhibition of ERK1/2, p38 ( MAPK ) or src kinases had no major effect on AP-1 mRNA expression in the Flexcell
Bhattacharyya et al., Biochem J 2002 : While ERK1/2 activation could be linked to enhanced DNA binding of activator protein-1 (AP-1), p38 MAPK signalling did not affect AP-1 DNA binding
Sanjo et al., Mol Cell Biol 2003 (Fetal Death...) : Recently, serine/threonine kinase TAK1 and TAK1 binding protein 1 and 2 (TAB1/2) have been identified as molecules involved in IL-1 induced TRAF6 mediated activation of AP-1 and NF-kappa B via mitogen activated protein ( MAP ) kinases and I kappa B kinases, respectively
Kikkawa et al., Am J Kidney Dis 2003 (Diabetic Nephropathies...) : We also found that inhibition of MAPK by PD98059, an inhibitor of MAPK, or mitogen activated extracellular regulated protein kinase kinase prevented enhancement of activated protein-1 (AP-1) DNA binding activity and fibronectin expression in cultured mesangial cells exposed to mechanical stretch in an in vivo model of glomerular hypertension
Tu et al., Cardiovasc Toxicol 2003 : Distinct roles of p42/p44 ( ERK ) and p38 MAPK in oxidant induced AP-1 activation and cardiomyocyte hypertrophy
Silvers et al., Neoplasia (New York, N.Y.) 2003 (Skin Neoplasms) : The role of JNK and p38 MAPK activities in UVA induced signaling pathways leading to AP-1 activation and c-Fos expression
Parameswaran et al., Cell Physiol Biochem 2003 : Both an AM-induced increase in AP-1 mRNA expression and AP-1 luciferase activities were inhibited by H89 ( protein kinase-A inhibitor ) and SB203580 ( p38 MAPK inhibitor )
Ma et al., J Immunol 2004 : Studies conducted to understand the regulation of AP-1 and NF-kappaB activation by JNK MAPK revealed that both DXM and SP600125 inhibited IL-12p40 gene transcription by inhibiting the activation of AP-1 and NF-kappaB transcription factors as revealed by luciferase reporter and gel mobility shift assays
Cannon et al., Oncogene 2004 (Lymphoma) : We show that vGPCR induced activation of AP-1 and CREB is mediated cooperatively by a Gq-ERK-1/2 and a Gi-PI3K-Src axis
Pufe et al., J Pathol 2004 (Osteoarthritis) : VEGF stimulation induced receptor phosphorylation, activation of the mitogen activated protein kinases ERK 1/2 , and long lasting activation of the transcription factor AP-1 ( activator protein-1 )
Ryoo et al., Cardiovasc Res 2004 : These data demonstrated that LDL stimulates SMCs to induce IL-8 production in dose- and time dependent manners at the transcription level and that the LDL signaling in hAoSMCs is conveyed via the generation of H2O2, the phosphorylation of p38 MAPK , the activation of AP-1 , and the participation of NF-kappaB
Fradette et al., Curr Drug Metab 2004 (Anoxia...) : The up-regulation of CYP3A6 implies a PTK- and p42/44MAPK dependent stabilization/activation, nuclear translocation of HIF-1 and AP-1 , binding to CYP3A6 promoter, and transactivation of the gene to induce CYP3A6 expression
Domínguez-Cáceres et al., Oncogene 2004 : However, it did not modify PRL stimulation of c-Fos mRNA expression or activation of Erk1/2 and Stat5
Park et al., Biochem Biophys Res Commun 2004 (MAP Kinase Signaling System) : Taken together, these results demonstrate that naturally occurring furosin has an inhibitory activity on both osteoclast differentiation and function through mechanisms involving inhibition of the RANKL induced p38MAPK and JNK/AP-1 activation as well as actin ring formation
Iles et al., Free Radic Biol Med 2005 : Downstream, MAPK activation leads to increased AP-1 binding, which mediates GCL induction
Sawai et al., Oncogene 2006 (Disease Progression...) : Overexpressed ILK enhances the IL-1alpha induced p38 MAPK phosphorylation more strongly through glycogen synthase kinase 3 ( GSK-3 ) activation, and subsequently induces AP-1 activation, which promotes aggressive capabilities of pancreatic cancer cells
Mossman et al., Am J Respir Cell Mol Biol 2006 (Lung Neoplasms...) : Work from our laboratories supports the concept that MAPK signaling and AP-1 transactivation by cigarette smoke and asbestos may synergize in lung epithelial cell injury, compensatory proliferation of lung epithelial cells, and carcinogenesis, supporting a mechanistic framework for the striking increases in lung cancer incidence in asbestos workers who smoke
Chen et al., J Biol Chem 2006 : The effects of Cybr on nuclear factor of activated T cells and AP-1 are dependent on MAPK activation, and enhanced activation of this cascade results in cooperation between the two transcription factors in the regulation of gene expression
Miyamoto et al., J Pharmacol Sci 2006 : Furthermore, activation of CaM kinase IV and MAPK increased phosphorylation of CREB ( cyclic AMP response element binding protein ) and expression of c-Fos by stimulation of gene expression
Vlotides et al., Mol Endocrinol 2006 (Pituitary Neoplasms) : EGF induced EGFR and ERK1/2 phosphorylation was followed by rapid MAPK kinase/ERK kinase dependent activation of Elk-1 and c-Fos
Gough et al., J Biol Chem 2007 (MAP Kinase Signaling System) : Thus, IFNgamma induced JAK1- and STAT1 independent activation of the ERK mitogen activated protein kinase pathway, phosphorylation of c-Jun, and activation of AP-1 DNA binding, which are important for the induction of a subset of ISGs
Sampey et al., Mol Pharmacol 2007 : Immunodetection and molecular analysis were used in this study to evaluate the hypothesis that 4-HNE modification of Erk-1/2 inhibits constitutive Erk-Est-like protein (Elk)-1 activating protein (AP)-1 signaling
Hou et al., Arch Biochem Biophys 2007 : The results demonstrated that PDGG suppressed COX-2 expression via blocking MAPK mediated activation of nuclear factor-kappaB (NF-kappaB), activator protein-1 (AP-1) and C/EBPdelta
Tirumurugaan et al., Am J Physiol Lung Cell Mol Physiol 2007 (MAP Kinase Signaling System) : We determined the role of mitogen activated protein kinase ( MAPK ) in the activation of NF-kappaB and AP-1 in the regulation of CD38 expression in HASM cells
Lee et al., J Mol Med (Berl) 2007 (Disease Models, Animal...) : Although C. difficile toxin A is known to induce nuclear factor-kappaB mediated chemokine expression in intestinal epithelial cells, little is known about its effect on the regulation of activator protein-1 (AP-1) by mitogen activated protein kinase ( MAPK )
Peng et al., Toxicology 2007 (Glioma) : Penta-acetyl geniposide induced apoptosis involving transcription of NGF/p75 via MAPK mediated AP-1 activation in C6 glioma cells
Lee et al., Cardiovasc Res 2007 : Down-regulation of NQO1 inhibits MMP-9 gene expression by suppressing activation of nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) , well-known key elements mediating MMP-9 gene expression in its promoter, via the p38 MAPK and JNK pathways
Suzuki et al., J Cell Physiol 2008 (Hemorrhage) : Two hrs thereafter, Kupffer cells and SMPhi production of IL-6, TNF-alpha, and IL-10, activation of MAPK ( p38, ERK-1/2, and JNK ), and transcription factors ( NF-kappaB and AP-1 ) were determined
Sun et al., Biochem Biophys Res Commun 2008 : We find that TNF induced oscillations in p65 and p50 recruitment to the CD38 promoter correlated with recruitment of MAPK induced AP-1 recruitment, as analyzed by quantitative ChIP analysis
Ding et al., FEMS Immunol Med Microbiol 2008 : The goal of this study was to investigate the effects of Helicobacter pylori and mitogen activated protein kinases ( MAPK ) on AP-1 subcomponents expression and AP-1 DNA binding activity in gastric epithelial cells
Wang et al., Glia 2009 (MAP Kinase Signaling System) : Here we report that oxLDL induces expression of proMMP-9 via a MAPK dependent AP-1 activation in rat brain astrocyte ( RBA ) -1 cells
Lee et al., J Dermatol Sci 2008 : However, in the AP-1 ( activator protein-1 ) luciferase reporter assay and in the Western blot analysis for mitogen activated protein kinases ( MAPKs ), carvacrol induced the activation of the AP-1 promoter and the phosphorylation of JNK and ERK1/2 ( p42/44 MAPK ), but did not induce the phosphorylation of p38 MAPK
Han et al., Toxicol Appl Pharmacol 2008 : Phosphatidylinositol 3 (PI3)-kinase, its downstream signaling molecule, Akt, and mitogen activated protein kinases ( MAPK ) were also significantly activated by the o, p'-DDT induced AP-1 and CRE activation
Skinner et al., Neuroscience 2008 : Induction of c-Fos was significantly reduced in the presence of inhibitors of protein kinase C, mitogen activated protein kinase ( MAPK ) and phospholipase C
Dragomir et al., Thromb Haemost 2008 : The MAPK inhibitors blocked the phosphorylation of IkBalpha and c-jun, indicating the role of MAPK in NF-kappaB and AP-1 activation in SMC under HG conditions
Nold-Petry et al., Proc Natl Acad Sci U S A 2009 : Increasing evidence demonstrates that interleukin (IL)-32 is a pro-inflammatory cytokine, inducing IL-1alpha, IL-1beta, IL-6, tumor necrosis factor (TNF)-alpha, and chemokines via nuclear factor (NF)-kappaB, p38 mitogen activated protein kinase ( MAPK ), and activating protein (AP)-1 activation
Dumesic et al., J Cell Biol 2009 (Neoplasms) : Unlike fibroblasts, in which Erk1/2 loss decreases cyclin D1 expression and induces G1/S arrest, Erk1/2 loss in epithelial cells reduces cyclin B1 and c-Fos expression and induces G2/M arrest while disrupting a gene regulatory network centered on cyclin B1-Cdc2
Khan et al., Mol Cell Biochem 2010 (Escherichia coli Infections...) : In this article, we have shown that EAEC induced activation of mitogen activated protein kinases ( MAPK ) ( ERK-1/2, JNK and p38MAPK ) in cultured human intestinal epithelial cells ( INT-407 ) leads to the induction of DNA binding activity of NF-kappaB and AP-1 , resulting in IL-8 production ... In this article, we have shown that EAEC induced activation of mitogen activated protein kinases ( MAPK ) ( ERK-1/2 , JNK and p38MAPK ) in cultured human intestinal epithelial cells ( INT-407 ) leads to the induction of DNA binding activity of NF-kappaB and AP-1 , resulting in IL-8 production
Son et al., Mol Cells 2009 (Lymphoma...) : Mitogen activated protein kinases ( MAPK ) affect the activation of activator protein-1 (AP-1) , which plays an important role in regulating a range of cellular processes
Kim et al., Neurochem Int 2010 (Parkinson Disease) : These results collectively suggest that ROS, PI3 kinase, NF-kappaB, and AP-1 are commonly involved in 6-OHDA- and MPP ( + ) -induced MMP-9 gene expression, and that p38 MAPK is differentially involved
Chen et al., Chem Biol Interact 2010 : Nitrosative stress induces osteoblast apoptosis through downregulating MAPK mediated NFkappaB/AP-1 activation and subsequent Bcl-X ( L ) expression
Yang et al., Atherosclerosis 2010 : N-acetylcysteine, SP600125 ( JNK inhibitor ) and SB203580 ( p38 MAPK inhibitor ) attenuated TNF-alpha induced DNA binding activities of both AP-1 and NF-kappaB
Wang et al., Biochem Biophys Res Commun 2010 : Mitogen activated protein kinase ( MAPK ) cascades play an important role in regulation of AP-1 activity through the phosphorylation of distinct substrates
Persichini et al., Neurosci Lett 2010 : Moreover, we have observed that IL-1ß regulates the expression of Cp and Fpn genes through ( i ) p38 MAPK mediated activation of C/EBP transcription factor, ( ii ) ERK1/2-, JNK1- and partially p38 MAPK dependent activation of AP-1 , and through ( iii ) activation of NF-?B partially mediated by p38 MAPK
Lee et al., Biochem Biophys Res Commun 2011 (Breast Neoplasms...) : DHAvD also suppressed activation of mitogen activated protein kinase ( MAPK ), and MAPK mediated nuclear factor-kappa B ( NF-?B ) and activator protein-1 (AP-1) activations in TPA treated MCF-7 cells
Ben et al., J Surg Res 2012 (Acute Lung Injury...) : Following intestinal I/R, phosporylation of p38 MAPK and activation of NF-?B and AP-1 were significantly inhibited in lung tissue from TLR4 mutant mice compared with WT controls
Lv et al., PloS one 2011 : In this study, the role of p38 MAPK in AP-1 activation and in the EMT in the human proximal tubular epithelial cell line ( HK-2 ) under high glucose concentration conditions is investigated
Butoi et al., Biochim Biophys Acta 2011 : Monocyte-SMC interaction induced the phosphorylation of p38MAPK and activation of AP-1 transcription factor
Jia et al., Int J Colorectal Dis 2012 (Colonic Neoplasms...) : Tissue factor/activated factor VIIa induces matrix metalloproteinase-7 expression through activation of c-Fos via ERK1/2 and p38 MAPK signaling pathways in human colon cancer cell
Zhu et al., Cytokine 2012 : Moreover, IL-1ß initiated AP-1 activation was blocked by p38 MAPK , ERK 1/2, or JNK inhibition, whereas NF-?B activity remained unaltered by all the above pathway specific inhibitors ... Moreover, IL-1ß initiated AP-1 activation was blocked by p38 MAPK, ERK 1/2 , or JNK inhibition, whereas NF-?B activity remained unaltered by all the above pathway specific inhibitors
Coste et al., Behav Brain Res 2012 (MAP Kinase Signaling System...) : Our results indicate that PAK 5 is involved in formalin induced inflammatory nociception through regulation of MAPK induced c-Fos-activation and formalin-specific TRP-channels
Frost et al., Proc Natl Acad Sci U S A 1994 : The role of ERK-1 and ERK-2 in wild-type ( wt ) Ha-Ras, phorbol 12-myristate 13-acetate ( PMA ), and serum induced AP-1 activity was studied ... By using eukaryotic expression constructs encoding wt ERK-1 and kinase-deficient mutants of ERKs 1 and 2, it was found that ERK-1 and ERK-2 activities are required for AP-1 activation stimulated by either wt Ha-Ras, PMA, or serum ... Overexpression of either kinase-deficient ERK-1 or kinase-deficient ERK-2 partially inhibited AP-1 activation by wt Ha-Ras but had no effect on PMA or serum induced activation
Luo et al., Cell Growth Differ 1997 (Astrocytoma) : CGP 41251 and tamoxifen selectively inhibit mitogen activated protein kinase activation and c-Fos phosphoprotein induction by substance P in human astrocytoma cells
Ito et al., Hepatology 1998 (Carcinoma, Hepatocellular...) : Furthermore, in 25 of 26 cases of HCC which genomic DNA was available, 22 cases without genomic DNA amplification exhibited positive correlation, not only between protein expression of c-Fos and cyclin D1, but also between MAPK/ERK activation and cyclin D1 expression
Kawata et al., J Biol Chem 1998 : The expression of c-Fos , a nuclear transcription factor, is induced by high pressure, and the induction is significantly inhibited by PD98059 ( 50 microM ), an upstream MAPK/extracellular signal regulated kinase kinase ( MEK ) inhibitor of MAPK
Delpedro et al., J Interferon Cytokine Res 1998 : In addition, deficient protein kinase C (PKC)-alpha, PKC-/betaI, and PKC-betaII activation, deficient mitogen activated protein kinase ( MAP-Kinase ) activation , and deficient expression of c-Fos and c-Jun was observed in LPS activated aged monocytes when compared with LPS activated young monocytes
Yi et al., J Immunol 1998 (Lymphoma, B-Cell) : CpG DNA also induces the phosphorylation of activating transcription factor-2, c-Jun, and mitogen activated protein kinase ( MAPK) activated protein kinase 2 as well as the activation of activator protein-1 (AP-1) DNA binding
Cook et al., Mol Cell Biol 1999 : In cells expressing a conditionally active form of Raf-1 ( DeltaRaf-1 : ER ), we observed that selective, sustained activation of Raf-MEK-MAPK was sufficient to induce expression of Fra-1, Fra-2, and JunB but, interestingly, induced little or no c-Fos or c-Jun