Gene interactions and pathways from curated databases and text-mining

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FOXP3 — MTOR

Text-mined interactions from Literome

Chen et al., J Invest Dermatol 2013 (Psoriasis) : mTORC2-PKBa/Akt1 Serine 473 Phosphorylation Axis Is Essential for Regulation of FOXP3 Stability by Chemokine CCL3 in Psoriasis
Perl et al., Curr Opin Rheumatol 2009 (Calcium Signaling...) : Mammalian target of rapamycin controls the expression T-cell receptor associated signaling proteins CD4 and CD3zeta through increased expression of the endosome recycling regulator HRES-1/Rab4 gene, mediates enhanced Ca2+ fluxing and skews the expression of tyrosine kinases both in T and B-cells, and blocks the expression of Foxp3 and the expansion of regulatory T-cells
Zeng et al., Nature 2013 (Inflammation) : By contrast, mTORC1 does not directly affect the expression of Foxp3 or anti- and pro-inflammatory cytokines in T ( reg ) cells, suggesting a non-conventional mechanism for T ( reg ) -cell functional regulation
Yurchenko et al., PloS one 2012 (Inflammation...) : Lastly, mTOR inhibition with the immunosuppressive drug, rapamycin, stabilizes Foxp3 expression in T ( REG ) cells and strongly inhibits IL-17 but not ROR?t expression in reprogrammed Foxp3 ( - ) T ( REG ) cells