Kiss et al., Mem Inst Oswaldo Cruz 2005
(Diabetes Complications) :
On the other hand, PARP activation results in inhibition of GAPDH by poly-ADP-ribosylation
Szabo et al., Br J Pharmacol 2009
(Diabetic Angiopathies) :
PARP mediated poly ( ADP-ribosyl ) ation and inhibition of glyceraldehyde-3-phosphate dehydrogenase importantly contributes to the development of diabetic vascular complications : it induces activation of multiple pathways of injury including activation of nuclear factor kappa B, activation of protein kinase C and generation of intracellular advanced glycation end products