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GCG — IGFBP1
Text-mined interactions from Literome
Hilding et al., Growth Horm IGF Res 2002
:
Glucagon and GLP-1
stimulate IGFBP-1 secretion in Hep G2 cells without effect on IGFBP-1 mRNA ... The
regulation of
IGFBP-1 secretion by
glucagon and GLP-1 appeared to be cAMP independent
Mounier et al., Endocrinology 2006
:
The expression of
IGF binding protein-1 (IGFBP-1) is
induced in rat liver by dexamethasone and
glucagon and is completely inhibited by 100 nM insulin
Kachra et al., Endocrinology 1991
:
To study the
role of GH and
glucagon in the regulation of IGF-I and
IGF-BP production, we examined IGF-I and IGF-BPs secreted by primary rat hepatocytes cultured in a serum-free medium ...
Glucagon ( 1 x 10 ( -8 ) M )
stimulated IGF-I secretion and
IGF-BP secretion
Westwood et al., J Clin Endocrinol Metab 1995
(Dwarfism...) :
Glucagon ( 1 mg, sc ),
increased IGFBP-1 from 27 ( range, 13-36.5 ) to 112 ( range, 100.5-129 ) micrograms/L ( 4.1-fold increase ; P = 0.009 ) after 90 min despite preceding insulin concentrations of more than 500 pmol/L, but again the IGFBP-1 remained in the highly phosphorylated form