Li et al., J Biol Chem 2001
:
GPIb-IX induced ERK2 phosphorylation is inhibited by PKG inhibitors and enhanced by overexpression of recombinant PKG. PKG activators also induce ERK phosphorylation, indicating that activation of MAPK pathway is downstream from PKG
Lian et al., Thromb Haemost 2001
(MAP Kinase Signaling System) :
Thus, in addition to alphavbeta3, EC GP Ibalpha initiates ERK activation, and regulates ERK induced EC migration on vWF
Mazharian et al., J Biol Chem 2005
(MAP Kinase Signaling System) :
The ERK2 activity required for platelet adhesion was dependent on the interaction of vWF with GPIb