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HBD — IRF6

Text-mined interactions from Literome

Mathews et al., Infect Immun 1999 : Human beta-defensins are expressed in oral tissues, and the proteins are secreted in saliva ; HBD-1 expression was constitutive, while HBD-2 expression was induced by IL-1beta and LPS
Liu et al., J Immunol 2003 : In normal fresh human skin, which contains Langerhans cells and other myeloid cell types, in addition to keratinocytes, LPS also induced HBD-2 in an IL-1 dependent manner
Ryan et al., Peptides 2003 (Plasmacytoma) : Production of human beta-defensin1 (HBD1) in response to LPS in monocytes, myeloid dendritic cells and plasmacytoid dendritic cells (PDC) was examined
MacRedmond et al., Respir Res 2005 : Here we provide evidence for the critical role of Toll-like receptor 4 (TLR4) in lipopolysaccharide (LPS) induced HBD2 expression by human A549 epithelial cells ... We also assessed the effect of over expressing wild type and/or mutant TLR4, MyD88 and/or Mal transgenes on LPS induced HBD2 expression in these cells ... We further implicate TLR4 in LPS induced HBD2 production by demonstrating HBD2 expression in LPS non-responsive HEK293 cells transfected with a TLR4 expression plasmid
MacRedmond et al., Respir Res 2007 (Pulmonary Disease, Chronic Obstructive) : The functional significance of this effect was demonstrated by impaired IL-8 and HBD2 induction in response to LPS
Aldhous et al., PloS one 2009 (Inflammatory Bowel Diseases) : LPS induced HBD2 production was significantly increased in CD ( p = 0.0375 ) but not UC ( p = 0.2017 ) ; this LPS induced response was augmented by nicotine in UC ( p = 0.0308 ) but not CD ( p = 0.6872 )
Han et al., Cytokine 2010 : HBD-1 was produced constitutively in vaginal epithelial cells and the production of HBD-1 was not influenced by LPS , 17beta-estradiol and progesterone, but the production of HBD-2 was increased inducibly by LPS
Kim et al., BJU Int 2011 (Prostatic Hyperplasia) : Bay11-7082, an NF-?B inhibitor prevented LPS induced HBD-2 production in RWPE-1 cells