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HIF1A — PI3

Text-mined interactions from Literome

Laughner et al., Mol Cell Biol 2001 (Breast Neoplasms) : Increased phosphatidylinositol 3-kinase (PI3K) and AKT or decreased PTEN activity in prostate cancer cells also increases HIF-1alpha expression by an undefined mechanism
Roy et al., Surgery 2003 (Anoxia...) : ( 1 ) Morphine inhibits hypoxia induced VEGF transcription, in part, through an HIF-1alpha mediated mechanism and ( 2 ) morphine inhibition of hypoxia induced HIF-1alpha may be mediated by inhibition of ERK 1,2 MAP kinase activity and PI3 kinase activity
Gao et al., Toxicol Appl Pharmacol 2004 (Ovarian Neoplasms) : To explore the mechanism of 4-OHE2 induced HIF-1alpha and VEGF-A expression, we studied whether phosphatidylinositol 3-kinase (PI3K) or mitogen activated protein kinase ( MAPK ) signaling pathways are involved in 4-OHE2 induced HIF-1alpha and VEGF-A expression
Hellwig-Bürgel et al., Cell Physiol Biochem 2005 : Thus, PI3K signaling is required for HIF-1alpha accumulation and VEGF synthesis, whereas MAPKK-1 signaling is required for VEGF synthesis only
Chen et al., Ann N Y Acad Sci 2005 : Ang II-stimulated HIF-1alpha accumulation was blocked by the phosphatidylinositol 3-kinase (PI-3K) inhibitors, Ly 294001, and wortmannin, suggesting that PI-3K was involved
Dimova et al., Thromb Haemost 2005 (MAP Kinase Signaling System...) : Thus, IGF-1 activates human PAI-1 gene expression through activation of the PI3-kinase and ERK1/2 via HIF-1alpha
Gort et al., Oncogene 2006 (Breast Neoplasms...) : Hypoxia-inducible factor-1alpha expression requires PI 3-kinase activity and correlates with Akt1 phosphorylation in invasive breast carcinomas ... Overexpression of dominant-active Akt1 restored HIF-1alpha expression, whereas inhibition of PI 3-kinase activity reduced hypoxic HIF-1alpha protein levels to a similar extent as serum deprivation
Kobayashi et al., Pathobiology 2006 (Adenocarcinoma...) : We investigated the role of phosphatidyl inositol-3 OH kinase (PI3K)-Akt signaling in the regulation of HIF-1alpha and VEGF expression in human gastric adenocarcinoma
Jin et al., Cell Signal 2007 : Inhibition of phosphatidylinositol 3-kinase (PI3K) by LY294002 and by a dominant negative PI3K mutant reduced the expression of Redd1 and activation of HIF-1alpha and Sp1 by CoCl ( 2 ) and HCD
Hasaneen et al., Am J Physiol Lung Cell Mol Physiol 2007 : Our results show : 1 ) a significant increase in human lung microvascular endothelial cell ( HMVEC-L ) proliferation, migration, and tube formation following incubation in conditioned media ( CM ) from HASM cells exposed to mechanical strain ; 2 ) mechanical strain of HASM cells induced VEGF expression and release ; 3 ) VEGF neutralizing antibodies inhibited the proliferation, migration, and tube formations of HMVEC-L induced by the strained airway smooth muscle CM ; 4 ) mechanical strain of HASM induced a significant increase in hypoxia-inducible factor-1alpha ( HIF-1alpha ) mRNA and protein, a transcription factor required for VEGF gene transcription ; and 5 ) mechanical strain of HASM induced HIF-1alpha/VEGF through dual phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) and ERK pathways
Belaiba et al., Mol Biol Cell 2007 (Anoxia) : Furthermore, inhibition of the phosphatidylinositol 3-kinase (PI3K)/AKT but not extracellular signal regulated kinase 1/2 pathway blocked the hypoxia dependent induction of HIF-1alpha mRNA and HIF-1alpha promoter activity, suggesting involvement of a PI3K/AKT regulated transcription factor
Wunderlich et al., Exp Dermatol 2008 : In accordance with these observations, wortmannin, an inhibitor of PI3-kinase effectively blocked the UVB induced increase in HIF-1alpha
Gelse et al., Osteoarthritis Cartilage 2008 (Cartilage Diseases) : The functional role of phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) and mitogen activated protein kinase ( MEK ) /extracellular signal regulated kinase ( ERK ) signaling on BMP-2/IGF-1 induced HIF-1alpha expression was assessed in vitro by employing specific inhibitors
Kuo et al., Biochem Biophys Res Commun 2009 (Breast Neoplasms) : Early work suggested that the phosphatidylinositol-3-kinase (PI3K) and mitogen activated protein kinase ( MAPK ) signaling pathways are involved in TNFalpha mediated HIF-1alpha accumulation and activation under normoxic conditions
Sumbayev et al., Eur J Immunol 2009 : ERK and p38 MAPK, but not reactive oxygen species ( ROS ), ASK1 or PI 3-kinase , were critical for IgE mediated accumulation of HIF-1alpha , although the latter crucially affected degranulation
Koshikawa et al., J Biol Chem 2009 (Carcinoma, Lewis Lung) : Stimulation of HIF-1alpha transcription by the ND6 mutation was mediated by overproduction of reactive oxygen species ( ROS ) and subsequent activation of phosphatidylinositol 3-kinase (PI3K)-Akt and protein kinase C ( PKC ) signaling pathways