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HIF1A — PTGS2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Jung et al., FASEB J 2003
(Inflammation...) :
Although
COX-2 inhibitors
attenuated IL-1 mediated
HIF-1alpha induction, prostaglandin E2 ( PGE2 ), a physiological product of COX-2, induced HIF-1alpha protein in a dose dependent manner
Wang et al., Biochem Biophys Res Commun 2004
:
Inhibition of
COX-2 activities would prevent vHL protein from degradation and
suppress HIF-1alpha up-regulation
Woo et al., Biochem Biophys Res Commun 2006
(Anoxia...) :
DFX induced the expression of COX-2 and accumulation of
HIF-1alpha protein in dose dependent manners, but hypoxia mimetic agent cobalt chloride ( CoCl2 )
induced accumulation of HIF-1alpha protein but not increase of
COX-2 expression
Naomoto et al., Med Hypotheses 2007
(Neoplasms...) :
On the other hand, tumor hypoxia often occurs in most tumors and
Cox-2 induced
HIF1alpha overexpression has recently been shown in various cancers
Brant et al., Toxicological sciences : an official journal of the Society of Toxicology 2009
:
Depletion of
HIF-1alpha using siRNA
blocked COX-2 induction by Ni and MALP-2 along with the release of VEGF, CXCL1, CXCL5, and CXCL8
Cheng et al., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2010
(Carcinoma, Squamous Cell...) :
HIF-1alpha regulate the expression and function of its downstream target genes (
COX-2 and VEGF ), which play a critical role in the angiogenesis of laryngeal carcinoma, metastases in the process of laryngeal cancer cell spreading to cervical lymph nodes