Gene interactions and pathways from curated databases and text-mining

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CASP12 — HTT

Text-mined interactions from Literome

Li et al., Hum Mol Genet 2000 (Huntington Disease) : Intranuclear huntingtin increases the expression of caspase-1 and induces apoptosis ... Here we report that intranuclear huntingtin induces the activation of caspase-3 and the release of cytochrome c from mitochondria in cultured cells ... We show that intranuclear huntingtin increases the expression of caspase-1 , which may in turn activate caspase-3 and trigger apoptosis ... We propose that the increased level of caspase-1 induced by intranuclear huntingtin contributes to HD-associated cell death
Zhang et al., EMBO J 2006 (Nerve Degeneration) : Huntingtin inhibits caspase-3 activation ... Huntingtin depletion resulted in caspase-3 activation, and overexpression of huntingtin resulted in caspase-3 inhibition ... Although reduction of huntingtin levels resulted in caspase-3 activation in all conditions examined, the cellular response was cell-type specific ... These data demonstrate that huntingtin inhibits caspase-3 activity, suggesting a mechanism whereby caspase mediated huntingtin depletion results in a detrimental amplification cascade leading to further caspase-3 activation, resulting in cell dysfunction and cell death
Leyva et al., Chem Biol 2010 (Disease Models, Animal...) : In this study, the identified nonpeptidic caspase inhibitors were used to confirm the role of caspase mediated Htt proteolysis in HD
Khoshnan et al., Neurobiol Dis 2011 (Disease Progression...) : Activation of IKKß by DNA damage triggers caspase dependent cleavage of WT and mutant Htt and enhances the accumulation of oligomeric fragments
Bodai et al., Bioessays 2012 (Huntington Disease...) : In response to mutant Htt , ERK is activated and directs a protective transcriptional response and inhibits caspase activation