Gene interactions and pathways from curated databases and text-mining

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IFNG — JUN

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Zhang et al., J Immunol 1999 : T cell proliferation and production of IL-2, IL-4, and IFN-gamma induced by both CD3 and CD3/CD28 ligation and the nuclear expression of the c-Jun and ATF-2 proteins are each blocked by the p38 MAPK inhibitor SB203580
Seppänen et al., Oncol Res 1998 (Adenocarcinoma...) : In the present study, we have investigated the effects of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ), interleukin-10 (IL-10) and -13 ( IL-13 ), transforming growth factor-beta1 ( TGF-beta1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha) on cell proliferation and induction of transcription factors AP-1 and NF-kappaB in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro
Wang et al., Hypertension 1999 (MAP Kinase Signaling System) : Tumor necrosis factor-alpha (TNF-alpha) alone can induce extracellular signal regulated kinase ( ERK ), p38 MAPK, and c-Jun N-terminal kinase activity in a rapid and transient manner, whereas interferon-gamma (IFN-gamma) can induce only ERK
Hamada et al., Toxicology 2000 : However, NF-kappaB was increased at 3 h while AP-1 ( Jun B and Jun D ) and CREB were increased at 15 h. Co-stimulation of 12j cells with rMu-IFN-gamma + Be increased the levels of NF-KB in 12j cell nuclei at 3 h, and the levels of AP-1 and CREB at 15 h, however, only Jun B was increased
Kim et al., J Immunol 2000 : EMSA using an AP-1-specific oligonucleotide demonstrated that IFN-gamma or LPS treatment increased the AP-1 binding activity
Nakahira et al., J Immunol 2002 : These results show that STAT4 up-regulates AP-1 mediated IFN-gamma promoter activation without directly binding to the promoter sequence, providing a mechanistic explanation for IL-12/IL-18 induced synergistic enhancement of IFN-gamma gene expression
Kaminuma et al., FEBS Lett 2002 : Vav induced activation of the human IFN-gamma gene promoter is mediated by upregulation of AP-1 activity
Yasumoto et al., J Biol Chem 1992 (Stomach Neoplasms) : Moreover, gel retardation analyses revealed that TNF alpha and IFN gamma synergistically induced the binding of NF-kB like as well as AP-1 like proteins bound to these sites
Jana et al., Free Radic Biol Med 2005 : All three cytokines alone induced the activation of AP-1 while IL-1beta and TNF-alpha but not IFN-gamma induced the activation of NF-kappaB ... Although IL-1beta and IFN-gamma alone induced the activation of AP-1 , the combination of these two cytokines ( IL-IF ) markedly inhibited the activation of AP-1
Yamada et al., J Urol 2005 (Urinary Bladder Neoplasms) : Although LPS and IFN-gamma alone marginally activated nuclear factor (NF)-kappaB but not AP-1, LPS plus IFN-gamma augmented NF-kappaB and AP-1
Sheu et al., Food Chem Toxicol 2006 (Glomerulonephritis) : Electrophoretic mobility shift assay experiments demonstrated that CLA ( 100 microM ) dramatically reduced activation of nuclear factor-kappaB (NF-kappaB), activator protein-1 (AP-1) and cAMP response element binding protein ( CREB ) induced by LPS/IFN-gamma ... Electrophoretic mobility shift assay experiments demonstrated that CLA ( 100 microM ) dramatically reduced activation of nuclear factor-kappaB (NF-kappaB), activator protein-1 (AP-1) and cAMP response element binding protein ( CREB ) induced by LPS/IFN-gamma
Bae et al., Planta Med 2006 : Electrophoretic mobility shift assays revealed that ginsenoside Rh2 significantly inhibited the LPS/IFN-gamma induced AP-1 DNA binding activity, while it enhanced the protein binding to CRE sequences
Hu et al., Immunity 2006 (Arthritis...) : IFN-gamma suppressed the activity of CREB and AP-1 , transcription factors that induce IL-10 expression and are regulated in part by MAPKs and GSK3
Gough et al., J Biol Chem 2007 (MAP Kinase Signaling System) : Herein we have shown that IFNgamma rapidly activated AP-1 DNA binding that required c-Jun but was independent of JAK1 and STAT1 ... IFNgamma induced c-Jun phosphorylation and AP-1 DNA binding required the MEK1/2 and ERK1/2 signaling pathways, whereas the JNK1/2 and p38 mitogen activated protein kinase pathways were dispensable ... Thus, IFNgamma induced JAK1- and STAT1 independent activation of the ERK mitogen activated protein kinase pathway, phosphorylation of c-Jun, and activation of AP-1 DNA binding, which are important for the induction of a subset of ISGs
Deng et al., Arterioscler Thromb Vasc Biol 2007 : IFNgamma blocked C-Jun and C/EBPbeta but not C-Fos or p50 NF-kappaB binding as determined by in vitro binding assays and chromatin immunoprecipitation assay
Liu et al., J Ethnopharmacol 2007 (Edema...) : To clarify the mechanisms involved, methanol extracts from fruiting body were found to inhibit the phosphorylation of extracellular signal regulated protein kinases ( ERK ), c-Jun NH2-terminal protein kinases (JNK) and signal transducer and activator of transcription-1 ( STAT-1 ) induced by LPS/IFN-gamma
Pedra et al., Infect Immun 2008 (Ehrlichiosis) : Here we show that c-Jun NH2-terminal kinase 2 (JNK2) inhibits IFN-gamma production during A. phagocytophilum infection
Nishida et al., Am J Physiol Gastrointest Liver Physiol 2008 : Furthermore, LY294002 suppressed both IL-1beta- and TNF-alpha induced NF-kappaB activation and IL-1beta-, TNF-alpha-, and IFN-gamma induced activated protein-1 (AP-1) activation
Seppänen et al., Acta Obstet Gynecol Scand 2008 (Carcinoma, Endometrioid...) : We were able to show that IFN-gamma , TGF-beta(1) and TNF-alpha all increased the binding activity of transcription factor AP-1 ( AP-1 )
Wu et al., Br J Pharmacol 2009 : Effects of tripterine were investigated on endothelial barrier function, inducible nitric oxide synthase (iNOS) expression, nicotinamide adenine dinucleotide phasphate ( NADPH ) oxidase activity, 3-nitrotyrosine formation, protein phosphatase type 2A (PP2A) activity, activation of extracellular regulated kinase (ERK), c-Jun terminal kinase (JNK) and Janus kinase ( Jak2 ), and degradation of IkappaB in microvascular endothelial cells exposed to pro-inflammatory stimulus [ lipopolysaccharide (LPS) + interferon gamma (IFNgamma) ] and on vascular permeability in air pouches of mice injected with LPS + IFNgamma
Do et al., J Nutr Biochem 2010 (Brain Neoplasms...) : In addition, fucoidan inhibited TNF-alpha- and IFN-gamma induced AP-1 , IRF-1, JAK/STAT and p38 mitogen activated protein kinase ( MAPK ) activation and induced scavenger receptor B1 (SR-B1) expression
Wallet et al., Cell Immunol 2010 (Inflammation) : IFNgamma primed, HMW-HA activated macrophages produced elevated levels of TNF and secreted the TH1 cytokine IL-12p70, while IFNgamma suppressed HMW-HA induced secretion of the regulatory cytokine IL-10 and activation of the transcription factor c-Jun
Jung et al., Int Immunopharmacol 2010 : Inhibition of these inflammatory mediators appears to be at the transcriptional level, since diosgenin decreased LPS/IFN-gamma induced NF-kappaB and AP-1 activity
de Wit et al., Exp Hematol 1996 : We conclude that the effects of IFN-gamma on the expression of the transcription factors AP-1 and NF-kappa B may be important for the modulatory effects of IFN-gamma on the cytokine expression in activated human monocytes
Barbulescu et al., J Immunol 1998 : These data suggest that both AP-1 and STAT4 are required for IL-12 dependent IFN-gamma promoter activity, whereas IL-18 causes direct activation via AP-1