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CASP2 — IL18

Text-mined interactions from Literome

Pirhonen et al., J Immunol 1999 : Since caspase-1 is known to cleave proIL-1 beta and proIL-18 into their mature, active forms, we analyzed the effect of a specific caspase-1 inhibitor on virus induced IL-1 beta and IL-18 production ... Furthermore, the virus induced activation of caspase-1 is required for the efficient production of biologically active IL-1 beta and IL-18
Zeuner et al., Cell Death Differ 1999 : In addition to the well established role of caspase-1 in the production of active IL-1beta and IL-18 in inflammation,4 an increasing number of reports has recently suggested that caspases may have a function outside of apoptosis
Tsutsui et al., Immunol Rev 2000 (Disease Models, Animal...) : LPS induces IL-18 secretion from Kupffer cells in a caspase-1 dependent manner
Lu et al., J Immunol 2000 : Chlamydia induced secretion of IL-18 from epithelial cells was regulated at the posttranscriptional level and was dependent on the activation of caspase-1
Seki et al., J Immunol 2001 : In this study, we investigated the mechanism underlying caspase-1 mediated IL-18 secretion
Fantuzzi et al., Eur J Immunol 2001 : In conclusion, IRF-1 regulates IL-18 production and activity mostly by modulating expression of caspase-1 and IL-18BP
Itoi et al., Blood 2001 (Acute Disease...) : Fas ligand induced caspase-1 dependent accumulation of interleukin-18 in mice with acute graft-versus-host disease ... These results suggest FasL mediated caspase-1 dependent IL-18 secretion in aGVHD in mice
Dreher et al., J Leukoc Biol 2002 : Our results show that infection by S. typhimurium causes caspase-1 dependent activation of IL-18 and triggers the release of IL-18 in human DCs
Guo et al., Blood 2003 : In the present study we confirm that Fas signaling induces both phenotypic and functional maturation of murine DCs, and we demonstrate that phenotypic maturation is associated with phosphorylation of extracellular signal regulated kinase ( ERK ) 1/2, activation of caspase-1 , and secretion of interleukin-beta ( IL-1beta )
Sekiyama et al., Immunity 2005 : Inhibitors of caspase-1 , reactive oxygen species, and P38 mitogen activated protein kinase ( MAPK ) suppressed stress induced accumulation of plasma IL-18
Niyonsaba et al., J Immunol 2005 (MAP Kinase Signaling System) : Furthermore, because IL-18 secretion induced by hBDs and LL-37 could not be suppressed by caspase-1 or caspase family inhibitors, and because these peptides failed to increase caspase-1 activity, we suggest that hBD- and LL-37 induced IL-18 secretion is probably via a caspase-1 independent pathway
Wang et al., Ann Thorac Surg 2005 (Reperfusion Injury) : Myocardial tissue was then assessed for products of p38 MAPK activation, expression of tumor necrosis factor, interleukin-1beta and interleukin-6, and activation of caspase-1, caspase-3 and caspase-11
Sekiyama et al., J Med Invest 2005 : Inhibitors of caspase-1 , reactive oxygen species and P38 MAPK prevented stress induced accumulation of plasma IL-18
Hodge et al., J Interferon Cytokine Res 2006 : IL-18 reduces NK cell self-destruction during NK-targeted cell killing, and in the presence of staurosporin, a potent apoptotic inducer, IL-18 reduces caspase-3 activity
Park et al., J Invest Dermatol 2007 : Furthermore, we suggest that ACTH induced IL-18 production is via the caspase-1 activation pathway, as IL-18 production induced by ACTH could be suppressed by caspase-1 inhibitor, and ACTH could increase caspase-1 activity
Edelstein et al., Nephrol Dial Transplant 2007 : We have recently demonstrated that the caspase-1 mediated production of IL-18 plays a deleterious role in ischaemic acute renal failure ( ARF ) which is independent of neutrophils and CD4+ T cells
Dinarello et al., Semin Nephrol 2007 (Inflammation...) : IL-18 is a member of the IL-1 family ; IL-1beta and IL-18 are related closely, and both require the intracellular cysteine protease caspase-1 for biological activity
Boost et al., Intensive Care Med 2007 (Endotoxemia) : Targeting caspase-1 by inhalation-therapy : effects of Ac-YVAD-CHO on IL-1 beta, IL-18 and downstream proinflammatory parameters as detected in rat endotoxaemia
Li et al., J Immunol 2007 : Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release
Nagai et al., J Biochem 2007 (Cataract...) : The gene expression levels causing IL-18 activation ( IL-18, IL-18 receptor and caspase-1 ) are increased at 32 days of age, and the expression of mature IL-18 protein in the UPL rat lenses also increases with ageing
Rupper et al., Infect Immun 2008 : The activation of caspase-1 by the detection of bacterial products through Nod-like receptors leads to the secretion of mature interleukin-1beta (IL-1beta) and IL-18 and the induction of rapid host cell death ( pyroptosis )
Kast et al., JOP : Journal of the pancreas 2008 (Acute Disease...) : Since ritonavir is well tolerated in short-term use it may therefore prove useful in treating acute pancreatitis by lowering caspase-1 mediated IL-18 formation and the many inflammatory mediators downstream from that
Yajima et al., Circulation 2008 (Inflammation...) : Apoptosis associated speck-like protein containing a caspase recruitment domain (ASC) is an adaptor protein that regulates caspase-1 dependent IL-1 beta and IL-18 generation ; however, the role of ASC in vascular injury remains undefined
Iigo et al., Biochimie 2009 (Neoplasms) : The increase of mature IL-18 by macrophages was inhibited by caspase-1 inhibitor : caspase-1 is known to cleave the proform of IL-18 to produce active mature IL-18
He et al., American journal of physiology. Renal physiology 2009 (Acute Kidney Injury) : We previously reported in ischemic acute kidney injury ( AKI ) in mice that caspase-1 mediated production of interleukin-18 (IL-18) is pathogenic and that macrophage depletion by liposome encapsulated clodronate ( LEC ) is protective
Halade et al., J Immunol 2010 (Lupus Erythematosus, Systemic...) : Further, FO-DHA lowered LPS mediated increases in serum IL-18 levels and caspase-1 dependent cleavage of pro-IL-18 to mature IL-18 in kidneys
Dinarello et al., Expert Rev Clin Immunol 2005 : IL-18 is a member of the IL-1 family ; IL-1beta and IL-18 are closely related, and both require the intracellular cysteine protease caspase-1 for biologic activity
Miao et al., Nat Immunol 2010 (Salmonella Infections) : Macrophages mediate crucial innate immune responses via caspase-1 dependent processing and secretion of interleukin 1ß (IL-1ß) and IL-18
Shushanov et al., Bull Exp Biol Med 2010 : Insulin-like growth factor-1 and insulin inhibit caspase-3/7 activation initiated by interleukin-1ß in the rat eye retinal neurons
Zhang et al., American journal of physiology. Renal physiology 2011 (Ureteral Obstruction) : Renal obstruction induced a significant increase in IL-18 production, renal tubular cell apoptosis, caspase activation, and FasL expression
Han et al., Exp Dermatol 2011 (Dermatitis, Atopic...) : The increased enzymatic activity of caspase-1 in the dorsal skin of the kanamycin administered mice increased the mRNA expressions of IL-1ß and IL-18
Eitel et al., Frontiers in microbiology 2010 : Inflammasomes regulate caspase-1 dependent production of the key inflammatory cytokines IL-1ß and IL-18 as well as pyroptotic cell death in L. monocytogenes infected cells
Zambetti et al., Immunol Res 2012 (Disease Models, Animal...) : The Nucleotide binding oligomerization domain, Leucine-rich Repeat and Pyrin domain containing ( NLRP ) family and corresponding inflammasomes are important intracellular sensors of microbial pathogens and stress signals that promote caspase-1 mediated release of IL-1ß and IL-18
Levinsohn et al., PLoS Pathog 2012 : Their activation in response to a wide range of intracellular danger signals leads to formation of the inflammasome, caspase-1 activation , rapid programmed cell death ( pyroptosis ) and maturation of IL-1ß and IL-18
Jacobs et al., J Leukoc Biol 2012 (Virus Diseases) : Upon pathogen infection, some NLR proteins form large complexes, called inflammasomes, which activate caspase-1 and induce the production of active IL-1ß and IL-18
Nasti et al., Photochem Photobiol 2012 (Inflammation) : Normal skin contains only low levels of inactive precursor forms of IL-1ß and IL-18 , which require caspase 1-mediated proteolysis for their maturation and secretion
Liao et al., Inflamm Res 2013 : Lipopolysaccharide/adenosine triphosphate mediated signal transduction in the regulation of NLRP3 protein expression and caspase-1 mediated interleukin-1ß secretion
Huang et al., Scientific reports 2013 : In the present study, the HSM extract suppresses IL-1ß and IL-18 secretion, and ATP induced activation of caspase-1
Lin et al., PloS one 2013 (Plaque, Atherosclerotic) : In in-vitro experiments showed that ox-LDL induced caspase-1 activation and this activation was required for ox-LDL induced macrophages lysis, IL-1ß and IL-18 production as well as DNA fragmentation
Piper et al., PloS one 2013 : Release of these cytokines was not dependent on cell death, and only IL-1ß and IL-18 release was dependent on caspase-1 catalytic activity
Silva et al., J Immunol 2013 (Chagas Disease...) : Following pathogen infection, NLRs form large molecular platforms, termed inflammasomes, which activate caspase-1 and induce the production of active IL-1ß and IL-18
Akita et al., J Biol Chem 1997 : Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells
Culhane et al., Mol Psychiatry 1998 : We demonstrate that caspase-1 also cleaves rat IL-18 in vitro and that the caspase inhibitor, zVAD-DCB inhibits this cleavage