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IL1A — PLD1

Text-mined interactions from Literome

Conquer et al., Osteoarthritis Cartilage 1994 : Although PMA is known to stimulate phospholipase D ( PLD ) activity in most cells, it is not known whether LPS and IL-1 also stimulate PLD activity, or whether PLD activity contributes to AA liberation and PGE2 production in chondrocytes ... In the present study we compared the effect of IL-1 , LPS and protein kinase C ( PKC ) activators ( PMA ), mezerein, phorbol dibutyrate on PGE2 synthesis and PLD activity in articular chondrocytes
Park et al., Mol Pharmacol 2002 : The results of this study indicate that in human amnion cells, IL-1 beta might activate PLD through an upstream protein kinase C to elicit p38 and finally induce COX-2 expression
Kang et al., Mol Cell Biol 2013 (Arthritis, Rheumatoid...) : IL-1ß enhanced the binding of NF-?B and ATF-2 to the PLD1 promoter, thereby enhancing PLD1 expression
Bursten et al., Am J Physiol 1994 : Evidence presented here indicates that stimulation of human mesangial cells by IL-1 results in activation of a phospholipase D ( PLD ) that hydrolyzes PE to phosphatidic acid ( PA )