Gene interactions and pathways from curated databases and text-mining

◀ Back to STAT1

IL1B — STAT1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Tian et al., J Immunol 2000 (Carcinoma, Hepatocellular) : IL-1 beta attenuates IFN-alpha beta induced antiviral activity and STAT1 activation in the liver : involvement of proteasome dependent pathway ... Furthermore, IL-1beta attenuated IFN-alphabeta induced STAT1 binding and tyrosine phosphorylation without affecting the level of STAT1 protein
Shen et al., Biochem J 2000 : Furthermore, IL-1beta selectively down-regulated the IL-6 induced tyrosine phosphorylation of STAT1 without affecting the level of STAT1 or tyrosine phosphorylation of STAT3 ... However, pretreatment with the proteasome inhibitor MG132 under conditions that prevented the IL-1beta dependent activation of the nuclear factor NF-kappaB also blocked the inhibitory effect of IL-1beta on IL-6 activated STAT1 ... In related experiments, the protein tyrosine phosphatase inhibitor Na ( 3 ) VO ( 4 ) also antagonized the inhibitory effect of IL-1beta on the activation of STAT1 by IL-6
Badgwell et al., Surgery 2002 (Escherichia coli Infections...) : The 2 groups of mice were analyzed for serum levels of interferon-gamma, tumor necrosis factor-alpha, and interleukin-1beta as well as activation of NFkappaB and STAT1 , 2 proinflammatory transcription factors
Yang et al., J Biol Chem 2004 : This activity of IL-1beta does not depend on IL-1beta dependent STAT1-serine phosphorylation but on NF-kappaB dependent gene induction
Joshi et al., J Interferon Cytokine Res 2006 : A role for Stat1 in the regulation of lipopolysaccharide induced interleukin-1beta expression ... Although both interferon-beta (IFN-beta) and IFN-gamma activate Stat1, the early appearance of IFN-beta in the circulation after LPS administration suggested its pivotal role in Stat1 mediated IL-1beta expression in vivo
Kanda et al., Endocrinology 2008 : IL-1beta induced serine phosphorylation of inhibitory kappaBalpha, STAT1 , and STAT3
Ravichandran et al., Indian J Exp Biol 2011 (Carcinoma...) : Detailed molecular analyses showed that IL-1beta increased expression of phosphorylated STAT1 ( Tyr701 and Ser727 ) and STAT3 ( Tyr705 and Ser727 ) both in total cell lysates and nuclear lysates
Rohn et al., J Immunol 1999 (Astrocytoma) : IL-1beta did not interfere with IFN-gamma receptor signal transduction, since tyrosine phosphorylation, nuclear translocation, and DNA binding of STAT-1alpha to an IFN-gamma activation sequence of the type IV CIITA promoter were not affected by IL-1beta