Li et al., Acta Biochim Biophys Sin (Shanghai) 2004
:
The results suggested that GST-PD-1 could competently block the interaction between PD-L1 and PD-1 and increase the production of IL-2 and IFN-gamma of phytohemagglutinin activated T cells
Chikuma et al., J Immunol 2009
:
PD-1 mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo
Ma et al., Immunology 2011
(Hepatitis C, Chronic) :
PD-1 negatively regulates interleukin-12 expression by limiting STAT-1 phosphorylation in monocytes/macrophages during chronic hepatitis C virus infection
Wei et al., Proc Natl Acad Sci U S A 2013
(Calcium Signaling) :
We observed that high levels of PD-1 expression were required to inhibit macrophage inflammatory protein 1 beta production, lower levels were required to block cytotoxicity and IFN-? production, and very low levels of PD-1 expression could inhibit TNF-a and IL-2 production as well as T-cell expansion