Gene interactions and pathways from curated databases and text-mining

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EGF — IL6ST

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: IL6ST → EGF (decreases) Olsen et al., Cell 2006*
    Evidence: We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database

Text-mined interactions from Literome

Grant et al., Oncogene 2002 (Breast Neoplasms...) : Furthermore, EGF unexpectedly induced tyrosine phosphorylation of gp130
French et al., Leukemia 2002 (MAP Kinase Signaling System...) : Additional studies revealed that EGF stimulation resulted in tyrosine phosphorylation of endogenous gp130 in cells expressing the chimeric receptor