◀ Back to GRB2
GRB2 — INSR
Pathways - manually collected, often from reviews:
-
BioCarta insulin signaling pathway:
Insulin/Insulin/Insulin Ra/Insulin Ra/Insulin Rb/Insulin Rb complex (INSR-INS)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
-
NCI Pathway Database Insulin Pathway:
Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1)
→
SHC (SHC1)
(modification, collaborate)
Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Kovacina et al., Biochem Biophys Res Commun 1993, Skolnik et al., Science 1993, Pronk et al., J Biol Chem 1993, Skolnik et al., EMBO J 1993, Ishihara et al., J Biol Chem 1997
Evidence: assay
-
NCI Pathway Database Insulin Pathway:
Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1)
→
GRB2 (GRB2)
(modification, collaborate)
Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Kovacina et al., Biochem Biophys Res Commun 1993, Skolnik et al., Science 1993, Pronk et al., J Biol Chem 1993, Skolnik et al., EMBO J 1993, Ishihara et al., J Biol Chem 1997
Evidence: assay
-
NCI Pathway Database Insulin Pathway:
Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1)
→
Insulin Receptor/Insulin/IRS1 complex (INSR-INS-IRS1)
(modification, collaborate)
Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Kovacina et al., Biochem Biophys Res Commun 1993, Skolnik et al., Science 1993, Pronk et al., J Biol Chem 1993, Skolnik et al., EMBO J 1993, Ishihara et al., J Biol Chem 1997
Evidence: assay
-
NCI Pathway Database Insulin Pathway:
Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1)
→
SHIP (INPP5D)
(modification, collaborate)
Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Kovacina et al., Biochem Biophys Res Commun 1993, Skolnik et al., Science 1993, Pronk et al., J Biol Chem 1993, Skolnik et al., EMBO J 1993, Ishihara et al., J Biol Chem 1997
Evidence: assay
-
NCI Pathway Database Insulin Pathway:
Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1)
→
SHC/SHIP complex (SHC1-INPP5D)
(modification, collaborate)
Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Kovacina et al., Biochem Biophys Res Commun 1993, Skolnik et al., Science 1993, Pronk et al., J Biol Chem 1993, Skolnik et al., EMBO J 1993, Ishihara et al., J Biol Chem 1997
Evidence: assay
-
NCI Pathway Database Insulin Pathway:
GRB2 (GRB2)
→
Insulin Receptor/Insulin/IRS1 complex (INSR-INS-IRS1)
(modification, collaborate)
Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Kovacina et al., Biochem Biophys Res Commun 1993, Skolnik et al., Science 1993, Pronk et al., J Biol Chem 1993, Skolnik et al., EMBO J 1993, Ishihara et al., J Biol Chem 1997
Evidence: assay
-
NCI Pathway Database Insulin Pathway:
Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos complex (INSR-INS-SHC1-SOS1-GRB2-IRS1)
→
None
(modification, activates)
Mahadev et al., J Biol Chem 2001
Evidence: assay
-
NCI Pathway Database Insulin Pathway:
GRB2 (GRB2)
→
Insulin Receptor/Insulin/SHC/GRB2/Sos1 complex (INSR-INS-SHC1-GRB2-SOS1)
(modification, collaborate)
-
NCI Pathway Database Insulin Pathway:
GRB2 (GRB2)
→
Insulin Receptor/Insulin/SHC complex (INSR-INS-SHC1)
(modification, collaborate)
-
NCI Pathway Database Insulin Pathway:
Insulin Receptor/Insulin/SHC/GRB2/Sos1 complex (INSR-INS-SHC1-GRB2-SOS1)
→
SOS1 (SOS1)
(modification, collaborate)
-
NCI Pathway Database Insulin Pathway:
Insulin Receptor/Insulin/SHC/GRB2/Sos1 complex (INSR-INS-SHC1-GRB2-SOS1)
→
Insulin Receptor/Insulin/SHC complex (INSR-INS-SHC1)
(modification, collaborate)
-
NCI Pathway Database Insulin Pathway:
IRS1 (IRS1)
→
Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B complex (INSR-INS-SHC1-GRB2-PTPN1-IRS1)
(modification, collaborate)
Hashimoto et al., J Biol Chem 1992, Hashimoto et al., Biochem J 1992, Kenner et al., J Biol Chem 1993
-
NCI Pathway Database Insulin Pathway:
SHC (SHC1)
→
Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B complex (INSR-INS-SHC1-GRB2-PTPN1-IRS1)
(modification, collaborate)
Hashimoto et al., J Biol Chem 1992, Hashimoto et al., Biochem J 1992, Kenner et al., J Biol Chem 1993
-
NCI Pathway Database Insulin Pathway:
GRB2 (GRB2)
→
Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B complex (INSR-INS-SHC1-GRB2-PTPN1-IRS1)
(modification, collaborate)
Hashimoto et al., J Biol Chem 1992, Hashimoto et al., Biochem J 1992, Kenner et al., J Biol Chem 1993
-
NCI Pathway Database Insulin Pathway:
GRB2 (GRB2)
→
Insulin Receptor/Insulin complex (INSR-INS)
(modification, collaborate)
Hashimoto et al., J Biol Chem 1992, Hashimoto et al., Biochem J 1992, Kenner et al., J Biol Chem 1993
-
NCI Pathway Database Insulin Pathway:
PTP1B (PTPN1)
→
Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B complex (INSR-INS-SHC1-GRB2-PTPN1-IRS1)
(modification, collaborate)
Hashimoto et al., J Biol Chem 1992, Hashimoto et al., Biochem J 1992, Kenner et al., J Biol Chem 1993
-
NCI Pathway Database Insulin Pathway:
Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B complex (INSR-INS-SHC1-GRB2-PTPN1-IRS1)
→
Insulin Receptor/Insulin complex (INSR-INS)
(modification, collaborate)
Hashimoto et al., J Biol Chem 1992, Hashimoto et al., Biochem J 1992, Kenner et al., J Biol Chem 1993
-
NCI Pathway Database Insulin Pathway:
Insulin Receptor/Insulin/SHC/GRB2/Sos1 complex (INSR-INS-SHC1-GRB2-SOS1)
→
HRAS/GTP complex (HRAS)
(modification, activates)
Wick et al., J Biol Chem 2001, Ouwens et al., J Biol Chem 1994, Yamauchi et al., J Biol Chem 1994, Pronk et al., Mol Cell Biol 1994, Sasaoka et al., J Biol Chem 1994
Evidence: assay
-
NCI Pathway Database Insulin Pathway:
Insulin Receptor/Insulin/SHC/GRB2/Sos1 complex (INSR-INS-SHC1-GRB2-SOS1)
→
HRAS/GDP complex (HRAS)
(modification, activates)
Wick et al., J Biol Chem 2001, Ouwens et al., J Biol Chem 1994, Yamauchi et al., J Biol Chem 1994, Pronk et al., Mol Cell Biol 1994, Sasaoka et al., J Biol Chem 1994
Evidence: assay
-
NCI Pathway Database Insulin Pathway:
Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos complex (INSR-INS-SHC1-SOS1-GRB2-IRS1)
→
SOS1 (SOS1)
(modification, collaborate)
Pronk et al., Mol Cell Biol 1994
Evidence: assay, physical interaction
-
NCI Pathway Database Insulin Pathway:
Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos complex (INSR-INS-SHC1-SOS1-GRB2-IRS1)
→
Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1)
(modification, collaborate)
Pronk et al., Mol Cell Biol 1994
Evidence: assay, physical interaction
-
NCI Pathway Database Insulin Pathway:
SOS1 (SOS1)
→
Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1)
(modification, collaborate)
Pronk et al., Mol Cell Biol 1994
Evidence: assay, physical interaction
-
NCI Pathway Database Insulin Pathway:
Insulin Receptor/Insulin/SHC/GRB10 complex (INSR-INS-SHC1-GRB10)
→
Insulin Receptor/Insulin/SHC/GRB2/Sos1 complex (INSR-INS-SHC1-GRB2-SOS1)
(modification, inhibits)
Wick et al., J Biol Chem 2001
Evidence: assay
-
NCI Pathway Database Insulin Pathway:
PTP1B (PTPN1)
→
Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B complex (INSR-INS-SHC1-GRB2-PTPN1-IRS1)
(modification, collaborate)
Goldstein et al., J Biol Chem 2000, Dadke et al., J Biol Chem 2000, Seely et al., Diabetes 1996, Bandyopadhyay et al., J Biol Chem 1997
Evidence: mutant phenotype, assay
-
NCI Pathway Database Insulin Pathway:
PTP1B (PTPN1)
→
Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1)
(modification, collaborate)
Goldstein et al., J Biol Chem 2000, Dadke et al., J Biol Chem 2000, Seely et al., Diabetes 1996, Bandyopadhyay et al., J Biol Chem 1997
Evidence: mutant phenotype, assay
-
NCI Pathway Database Insulin Pathway:
Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B complex (INSR-INS-SHC1-GRB2-PTPN1-IRS1)
→
Insulin Receptor/Insuli/IRS1/GRB2/SHC complex (INSR-INS-SHC1-GRB2-IRS1)
(modification, collaborate)
Goldstein et al., J Biol Chem 2000, Dadke et al., J Biol Chem 2000, Seely et al., Diabetes 1996, Bandyopadhyay et al., J Biol Chem 1997
Evidence: mutant phenotype, assay
-
NCI Pathway Database Insulin Pathway:
Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos complex (INSR-INS-SHC1-SOS1-GRB2-IRS1)
→
HRAS/GTP complex (HRAS)
(modification, activates)
Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Pronk et al., Mol Cell Biol 1994, Sasaoka et al., J Biol Chem 1994, Myers et al., Mol Cell Biol 1994
Evidence: assay
-
NCI Pathway Database Insulin Pathway:
Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos complex (INSR-INS-SHC1-SOS1-GRB2-IRS1)
→
SHC/SHIP complex (SHC1-INPP5D)
(modification, activates)
Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Pronk et al., Mol Cell Biol 1994, Sasaoka et al., J Biol Chem 1994, Myers et al., Mol Cell Biol 1994
Evidence: assay
-
NCI Pathway Database Insulin Pathway:
Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos complex (INSR-INS-SHC1-SOS1-GRB2-IRS1)
→
HRAS/GDP complex (HRAS)
(modification, activates)
Wada et al., Endocrinology 1999, Sharma et al., Mol Endocrinol 2005, Pronk et al., Mol Cell Biol 1994, Sasaoka et al., J Biol Chem 1994, Myers et al., Mol Cell Biol 1994
Evidence: assay
-
WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway:
FGFR2/KDR/INSR/FGFR3/IGF1R/KIT/FGFR1/EPHA2/EGFR/CSF1R/FGFR4/FLT1/FLT4/NGFR/MET/PDGFRA/PDGFRB/TEK
→
GRB2
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Skolnik et al., Science 1993
:
In contrast to the activated epidermal growth factor receptor that binds the GRB2-Sos complex directly, activation of the
insulin receptor results in the interaction of
GRB2-Sos with IRS-1 and Shc, thus linking the insulin receptor to Ras signaling pathways
Skolnik et al., EMBO J 1993
:
The interactions between
GRB2 and these two proteins
require ligand activation of the
insulin receptor and are mediated by the binding of the SH2 domain of GRB2 to phosphotyrosines on both IRS-1 and Shc