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ITGA4 — PARP1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
de Bruyn et al., J Biol Chem 2002
:
In T-lymphocytes the Ras-like small GTPase
Rap1 plays an essential role in stimulus induced inside-out activation of integrin LFA-1 ( alpha ( L ) beta ( 2 ) ) and
VLA-4 ( alpha ( 4 ) beta ( 1 ) ) ... These findings indicate that available levels of GTP bound
Rap1 are
required for the direct activation of LFA-1 and
VLA-4
Schultess et al., Blood 2005
:
The Ras-like guanine-nucleotide binding protein
Rap1 controls
integrin alpha ( IIb ) beta3 activity and platelet aggregation
Danielewski et al., Thromb Haemost 2005
(Calcium Signaling) :
Since
Rap1 controls the function of
integrin alpha ( IIb ) beta3, we propose that Rap 1 inhibition might play a central role in the anti-aggregatory actions of NO/cGMP