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ERBB2 — ITGA6

Pathways - manually collected, often from reviews:

• NCI Pathway Database a6b1 and a6b4 Integrin signaling: alpha6/beta4 Integrin complex (ITGA6-ITGB4) → ErbB2 (ERBB2) (modification, activates) Russell et al., J Cell Sci 2003, Yoon et al., Cancer Res 2006
  Evidence: assay
• NCI Pathway Database a6b1 and a6b4 Integrin signaling: ErbB2 (ERBB2) → alpha6/beta1 Integrin complex (ITGA6-ITGB1) (proteasomal ubiquitin-dependent protein catabolic process, collaborate)
  Shimizu et al., Oncogene 2003*
  Evidence: assay

Text-mined interactions from Literome

Yoon et al., Cancer Res 2006 (Breast Neoplasms...) : We identified a novel mechanism by which integrin alpha(6)beta ( 4 ) regulates ErbB2 expression, Ras activation, and the invasion of breast carcinoma cells ... ErbB2 , a binding partner of epidermal growth factor receptor (EGFR), and EGFR modulated Ras activity, and integrin alpha(6)beta ( 4 ) regulated phospho-EGFR level without affecting EGFR expression ... We also found that integrin alpha(6)beta ( 4 ) is involved in ErbB2 expression ... These results show that integrin alpha(6)beta ( 4 ) regulates ErbB2 through translational control ... In summary, we propose a novel mechanism for ErbB2 up-regulation and Ras activation in serum depleted breast cancer cells ; integrin alpha(6)beta ( 4 ) regulates the expression of ErbB2 and the subsequent phosphorylation of EGFR and activation of Ras
Vafa et al., Int J Oncol 1998 (Prostatic Neoplasms) : Overexpression of p185erbB2/neu in the NbE prostatic epithelial cell line increases cellular spreading and the expression of integrin alpha6beta1