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ITPR3 — PRKAR1A

Text-mined interactions from Literome

Soulsby et al., Cell Calcium 2007 : IP3R3, however, is known to be phosphorylated by PKA at three sites ( S916, S934, and S1832 ) and, thus, we examined how phosphorylation of these sites affects Ca2+ mobilization in DT40-3KO cells stably expressing either exogenous wild-type or mutant IP3R3s ; an antibody raised against phospho-serine 934 of IP3R3 was used to demonstrate that the exogenous IP3R3s are strongly phosphorylated in response to PKA activation
Chaloux et al., Biol Cell 2007 : The purpose of the present study was to investigate the effect of PKA ( protein kinase A ) on the activity of IP(3)R-3 in RINm5F cells ... The PKA induced enhancement of IP(3)R-3 activity was also observed in intact RINm5F cells stimulated with carbachol and epidermal growth factor, two agonists that use different receptor types to activate phospholipase C
Matsumoto et al., Cell Res 2012 (Calcium Signaling) : A recent report in Nature showed that PKA dependent phosphorylation of the inositol-1,4,5-trisphosphate receptor ( InsP3R ) induces Ca mobilization, leading to increase in the phosphatase activity of calcineurin and the subsequent dephosphorylation of CRTC2, thereby resulting in the induction of gluconeogenic gene expression