Gene interactions and pathways from curated databases and text-mining

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LIPE — PRKAG2

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Watt et al., FASEB J 2004 : The exercise induced increase in HSL activity was attenuated by AMPK alpha-2 activation in LG ... To confirm the apparent effect of AMPK on HSL activity, we performed experiments in muscle cell culture
Roepstorff et al., J Physiol 2004 : The main purpose of the present study was to investigate the role of 5'AMP activated protein kinase (AMPK) in the regulation of muscle HSL activity and Ser565 phosphorylation ( the presumed AMPK target site ) in healthy, moderately trained men during 60 min bicycling ( 65 % ) ... Alternatively, other factors including ERK may have counterbalanced any effect of AMPK on HSL activity
Watt et al., Am J Physiol Endocrinol Metab 2006 : We investigated the effects of adrenergic stimulation and AMPK activation in vitro and in circumstances where AMPK activity and catecholamines are physiologically elevated in humans in vivo ( during physical exercise ) on HSL activity and phosphorylation at Ser ( 563 ) and Ser ( 660 ), the PKA regulatory sites, and Ser ( 565 ), the AMPK regulatory site ... AMPK inhibited epinephrine induced HSL activity in L6 myotubes and was associated with reduced HSL Ser ( 660 ) but not Ser ( 563 ) phosphorylation ... HSL activity was reduced in L6 myotubes expressing constitutively active AMPK, confirming the inhibitory effects of AMPK on HSL activity ... Conversely, in 3T3-L1 adipocytes, AMPK activation after epinephrine stimulation did not prevent HSL activity or glycerol release, which coincided with maintenance of HSL Ser ( 660 ) phosphorylation