Gene interactions and pathways from curated databases and text-mining

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LRPPRC — MAPK8

Text-mined interactions from Literome

Omori et al., J Biol Chem 2004 : High glucose enhances interleukin-6 induced vascular endothelial growth factor 165 expression via activation of gp130 mediated p44/42 MAPK-CCAAT/enhancer binding protein signaling in gingival fibroblasts ... Our findings suggest that the HG condition indirectly increases VEGF expression via activation of gp130 mediated p44/42 MAPK-CCAAT/enhancer binding protein signaling in HGFs
Schiemann et al., J Biol Chem 1997 : Expression of receptors lacking this region or of chimeric gp130 ( Y118F ) point mutants inhibited MAPK activity by approximately 55 %, suggesting that Tyr-118, but not box 3, was required during activation of MAPK by gp130