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HSP90AA1 — MAP3K7

Pathways - manually collected, often from reviews:

• WikiPathways EBV LMP1 signaling: Complex of MAP3K7-TAB1-MAP3K3-TRAF6 → Complex of IKBKG-CHUK-IKBKB-HSP90AA1 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: Complex of MAP3K7-CDC37-FKBP5-HSP90AA1-HSP90AB1-TAB1-TAB2 Bouwmeester et al., Nat Cell Biol 2004
• IRef Biogrid Interaction: MAP3K7 — HSP90AA1 (physical association, affinity chromatography technology) Liu et al., FEBS Lett 2008
• MIPS CORUM TNF-alpha/NF-kappa B signaling complex 7: TNF-alpha/NF-kappa B signaling complex 7 complex (CDC37-FKBP5-HSP90AA1-HSP90AB1-MAP3K7-TAB1-TAB2-TAB3) Bouwmeester et al., Nat Cell Biol 2004
• IRef Corum Interaction: Complex of HSP90AA1-MAP3K7-TAB1-CDC37-FKBP5-HSP90AB1-TAB3-TAB2 (association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Dip Interaction: MAP3K7 — HSP90AA1 (physical association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Hprd Interaction: Complex of 57 proteins (in vivo) Bouwmeester et al., Nat Cell Biol 2004
• IRef Intact Interaction: Complex of CDC37-HSP90AA1-MAP3K7-TAB2-TAB1 (association, anti bait coimmunoprecipitation) Liu et al., FEBS Lett 2008
• IRef Intact Interaction: Complex of TAB1-MAP3K7-HSP90AA1-CDC37 (association, anti bait coimmunoprecipitation) Liu et al., FEBS Lett 2008
• IRef Intact Interaction: MAP3K7 — HSP90AA1 (physical association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Intact Interaction: Complex of CDC37-CDC37-HSP90AA1-MAP3K7-MAP3K7-HSP90AA1 (association, pull down) Liu et al., FEBS Lett 2008
• IRef Ophid Interaction: MAP3K7 — HSP90AA1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: MAP3K7 — HSP90AA1 (aggregation, confirmational text mining) Bouwmeester et al., Nat Cell Biol 2004

Text-mined interactions from Literome

Shi et al., Mol Immunol 2009 : Silencing Hsp90 expression through RNA interference ( RNAi ) also down-regulated TAK1 , as well as attenuated IL-1beta induced phosphorylation of c-Jun NH ( 2 ) -terminal kinase ( JNK ) and p38 MAPKs, and degradation of IkappaBalpha
Liu et al., FEBS Lett 2008 (Inflammation) : However, Hsp90 is not required for the activation of TAK1 as short exposure to the Hsp90 inhibitor, 17- ( allylamino ) -17-demethoxygeldanamycin ( 17-AAG ) did not affect its activation by LPS or IL-1