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MCAT — TNF

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Iwasaki et al., Curr Neurovasc Res 2005 (Hypertension, Pulmonary) : MCT treatment caused infiltration of inflammatory cells, fibrosis of the interstitium, and pulmonary arterial wall thickening with marked elevation of right ventricular ( RV ) pressure, which are characteristics of MCT induced PH. Gene expression of tumor necrosis factor-alpha (TNF-alpha) as well as DNA binding activity of nuclear factor-kappaB (NF-kappaB) increased at 1 week after MCT treatment, reached a maximum at 2 weeks, and then decreased to the pretreatment level at 3 weeks
Tukov et al., Toxicol In Vitro 2006 (Inflammation) : MCT by itself did not affect release of TNF-alpha but increased the response to LPS
Baybutt et al., Curr Pharm Des 2007 (Disease Models, Animal...) : RA influences production of an important Th1 cytokine, IFN_, and demonstrated the greatest limitation of MCT induced TNFalpha
Thibault et al., Gastroenterology 2007 (Colitis...) : IFN-gamma and TNF-alpha did not affect MCT1 mRNA stability but rather down-regulated gene transcription
Kono et al., Translational research : the journal of laboratory and clinical medicine 2010 (Colitis) : Induction of interleukin 1beta (IL-1beta), TNF-alpha , and macrophage inflammatory protein-2 ( MIP-2 ) in the colon was attenuated by dietary MCT