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MCAT — TNF
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Iwasaki et al., Curr Neurovasc Res 2005
(Hypertension, Pulmonary) :
MCT treatment caused infiltration of inflammatory cells, fibrosis of the interstitium, and pulmonary arterial wall thickening with marked elevation of right ventricular ( RV ) pressure, which are characteristics of
MCT induced PH. Gene expression of
tumor necrosis factor-alpha (TNF-alpha) as well as DNA binding activity of nuclear factor-kappaB (NF-kappaB) increased at 1 week after MCT treatment, reached a maximum at 2 weeks, and then decreased to the pretreatment level at 3 weeks
Tukov et al., Toxicol In Vitro 2006
(Inflammation) :
MCT by itself did not
affect release of
TNF-alpha but increased the response to LPS
Baybutt et al., Curr Pharm Des 2007
(Disease Models, Animal...) :
RA influences production of an important Th1 cytokine, IFN_, and demonstrated the greatest limitation of
MCT induced
TNFalpha
Thibault et al., Gastroenterology 2007
(Colitis...) :
IFN-gamma and
TNF-alpha did not
affect MCT1 mRNA stability but rather down-regulated gene transcription
Kono et al., Translational research : the journal of laboratory and clinical medicine 2010
(Colitis) :
Induction of interleukin 1beta (IL-1beta),
TNF-alpha , and macrophage inflammatory protein-2 ( MIP-2 ) in the colon was
attenuated by dietary
MCT