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E2F1 — MCL1

Pathways - manually collected, often from reviews:

• NCI Pathway Database E2F transcription factor network: E2F1/DP complex (E2F1-TFDP2_TFDP1) → MCL1 (MCL1) (transcription, inhibits) Croxton et al., Oncogene 2002*
  Evidence: mutant phenotype, reporter gene, physical interaction

Text-mined interactions from Literome

Croxton et al., Oncogene 2002 : Here we show that while E2F1 can repress the Mcl-1 promoter, other members of the E2F family ( such as E2F4 ) can not
Ma et al., Mol Cancer Ther 2003 (Carcinoma, Non-Small-Cell Lung...) : Likewise, recent studies from our laboratory demonstrated that E2F1 leads to transcriptional repression of Mcl-1 and subsequently apoptosis