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MMP14 — RHOA

Text-mined interactions from Literome

Annabi et al., J Neurochem 2005 (Brain Neoplasms...) : We show that the overexpression of the GTPase RhoA up-regulated MT1-MMP expression and triggered CD44 shedding from the U-87 glioma cell surface
Muñoz-Nájar et al., Oncogene 2006 (Breast Neoplasms...) : Inhibition of the small GTPase RhoA eliminated the hypoxia induced invasion and blocked the localization of MT1-MMP to the plasma membrane
Ando et al., J Atheroscler Thromb 2011 : In this study, we hypothesized that MT1-MMP may mediate RhoA and Rac1 activation and their downstream events in thrombin stimulated endothelial cells ... Silencing of MT1-MMP attenuated thrombin triggered RhoA and Rac1 activation, resulting in the attenuation of downstream events including Ca ( 2+ ) signaling, NADPH oxidase activity, ROS generation, and TF and PAI-1 expression ... The present study shows that MT1-MMP mediates the RhoA/Ca ( 2+ ) and Rac1/NADPH oxidase dependent signaling pathways in thrombin induced vascular responses
Serratì et al., Arthritis Rheum 2013 (Scleroderma, Systemic) : Motility increase required Rac1 activation and RhoA inhibition and was inhibited by an MMP inhibitor