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MMP9 — NOS2
Text-mined interactions from Literome
Keilhoff et al., Dev Neurobiol 2007
(Sciatic Neuropathy...) :
Compared with uninjured and PBS treated injured nerves, the minocycline treated injured nerve showed : ( i ) a decrease in macrophage recruitment and activation, probably resulting from inhibition of blood-brain-barrier break-down via reduced MMP2 and
MMP9 induction, inhibition of revascularization via additional reduction of VEGF induction, and
inhibition of
inducible NO synthase (iNOS) induction ; ( ii ) reduced activation of phagocytic Schwann cells, probably by inhibition of iNOS, MMP2 and MMP9 expression ; ( iii ) a slowed Wallerian degeneration ; and subsequently, ( iv ) a diminished nerve regeneration
Chen et al., Tokai J Exp Clin Med 2008
(Plaque, Atherosclerotic) :
Activation of inducible
nitric oxide synthase increases MMP-2 and
MMP-9 levels in ApoE-knockout mice
Moore et al., Gastroenterology 2011
(Disease Models, Animal...) :
Induction of
MMP-9 expression
requires inducible
nitric oxide synthase
Givvimani et al., International journal of physiology, pathophysiology and pharmacology 2011
:
Hcy increases
iNOS ,
activates matrix metalloproteinase ( MMP ) , disrupts connexin-43 and increases collagen/elastin ratio