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MSTN — PRKAB1

Text-mined interactions from Literome

Miyake et al., Cell Tissue Res 2012 : AMPK activation by AICAR inhibits myogenic differentiation and myostatin expression in cattle ... AMP activated protein kinase (AMPK) regulates metabolism in skeletal muscle, and myostatin (MSTN) negatively regulates skeletal muscle development and growth ... Therefore, AMPK activation inhibits myogenic differentiation but may suppress MSTN expression to balance muscle development
Das et al., Biochem Biophys Res Commun 2012 : We hypothesized that AMPK stimulates myostatin expression, which provides an explanation for the negative role of AMPK in muscle growth ... In addition, ectopic expression of AMPK wild-type a subunit ( enhancing AMPK activity ) and AMPK K45R mutant ( knockdown AMPK activity ) enhanced and reduced myostatin expression, respectively ... These results indicate that AMPK stimulates myostatin expression in C2C12 cells, providing an explanation for the negative effect of AMPK on muscle growth
Shan et al., FASEB J 2013 : Within the muscle, Mstn ( -/- ) leads to increased expression of AMPK and its phosphorylation, which subsequently activates PGC1a and Fndc5