Gene interactions and pathways from curated databases and text-mining

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MTA1 — NOS2

Text-mined interactions from Literome

Moreno et al., Ann Neurol 2006 (Disease Models, Animal...) : Indeed, MTA suppressed the production of proinflammatory genes and cytokines ( interferon-gamma, tumor necrosis factor-alpha, and inducible nitric oxide synthase ) and increased the production of antiinflammatory cytokines ( interleukin-10 )
Minamikawa et al., J Endod 2009 : MTA significantly caused an up-regulation of cyclooxygenase-2 (COX-2) and inducible form of nitric oxide synthase ( iNOS ) mRNA expression ... Curucumin, an inhibitor of NF-kappaB activation, suppressed MTA induced COX-2 and iNOS mRNA expressions
Bui-Nguyen et al., J Biol Chem 2010 (Liver Neoplasms) : Here we provide evidence that MTA1 is a positive regulator of iNOS transcription and plays a mechanistic role in HBx stimulation of iNOS expression and activity ... We observed that miR-661 controls of MTA1 expression contributed to the expression and activity of iNOS in HBx expressing HepG2 cells ... Accordingly, depletion of MTA1 by either miR-661 or siRNA in HBx expressing cells severely impaired the ability of HBx to modulate the endogenous levels of iNOS and nitrite production ... Together, these findings reveal an inherent role of MTA1 in HBx regulation of iNOS expression and consequently its function in the liver cancer cells