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MTA1 — NOS2
Text-mined interactions from Literome
Moreno et al., Ann Neurol 2006
(Disease Models, Animal...) :
Indeed,
MTA suppressed the production of proinflammatory genes and cytokines ( interferon-gamma, tumor necrosis factor-alpha, and inducible
nitric oxide synthase ) and increased the production of antiinflammatory cytokines ( interleukin-10 )
Minamikawa et al., J Endod 2009
:
MTA significantly
caused an up-regulation of cyclooxygenase-2 (COX-2) and inducible form of
nitric oxide synthase ( iNOS ) mRNA expression ... Curucumin, an inhibitor of NF-kappaB activation, suppressed
MTA induced COX-2 and
iNOS mRNA expressions
Bui-Nguyen et al., J Biol Chem 2010
(Liver Neoplasms) :
Here we provide evidence that
MTA1 is a positive regulator of iNOS transcription and
plays a mechanistic role in HBx stimulation of
iNOS expression and activity ... We observed that miR-661 controls of
MTA1 expression
contributed to the expression and activity of
iNOS in HBx expressing HepG2 cells ... Accordingly, depletion of
MTA1 by either miR-661 or siRNA in HBx expressing cells severely
impaired the ability of HBx to modulate the endogenous levels of
iNOS and nitrite production ... Together, these findings reveal an inherent
role of
MTA1 in HBx regulation of
iNOS expression and consequently its function in the liver cancer cells