Gene interactions and pathways from curated databases and text-mining

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MAPK1 — NFKBIA

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Wang et al., Allergy 2005 : IL-6 gene expression was assessed by reverse transcriptase-polymerase chain reaction ( RT-PCR ), and p38 MAPK activity and inhibitor (I)kappaB-alpha induction were evaluated by Western blot
Calleros et al., Cell Signal 2006 (MAP Kinase Signaling System) : Here, we found that inhibition of p38 MAPK with the specific inhibitor SB203580 blocked the increase in NFkappaB activity, IkappaBalpha degradation and p65/NFkappaB translocation to the nucleus induced by cholesterol depletion
Tsuji et al., Int Immunopharmacol 2007 : IL-1beta induced phosphorylation of the mitogen activated protein ( MAP ) kinases , IkappaBalpha , c-Jun and Akt
Adhikary et al., J Leukoc Biol 2008 (Corneal Diseases...) : To determine the role of MAPKs in TLR- induced corneal inflammation, we stimulated human corneal epithelial (HCE) cells with TLR2 ligands, tripalmitoyl-S-glycero-Cys- ( Lys ) 4 ( Pam3Cys ) or inactivated Staphylococcus aureus, and examined the time course of expression of MAPKs and the effect of MAPK inhibition on IkBalpha degradation and CXC chemokine production
Dragomir et al., Thromb Haemost 2008 : The MAPK inhibitors blocked the phosphorylation of IkBalpha and c-jun, indicating the role of MAPK in NF-kappaB and AP-1 activation in SMC under HG conditions
Schwenger et al., Mol Cell Biol 1998 : Induction of p38 MAPK activation and inhibition of TNF induced IkappaB alpha degradation were demonstrated with pharmacologically achievable doses of NaSal
Lee et al., Proc Natl Acad Sci U S A 1998 : We have previously shown that mitogen activated protein kinase/ERK kinase kinase 1 ( MEKK1 ) can induce both this site-specific phosphorylation of IkappaB alpha at Ser-32 and Ser-36 in vivo and the activity of a high molecular weight IkappaB kinase complex in vitro